平继辉 - 南京农业大学

个人简介

平继辉，南京农业大学高层次引进人才。2008 年毕业于南京农业大学获博士学位，2008年 12月至 2011年 7月加拿大渥太华大学(University of Ottawa)博士后，2011 年 7 月至 2014 年 7 月美国威斯康星大学麦迪逊分校(University ofWisconsin-Madison)博士后，2014 年 8 月 2016 年 8 月美国威斯康星大学麦迪逊分校助理科学家(Assistant Scientist)。2016 年 8 月至今南京农业大学动物医学院教授。长期致力于流感病毒的遗传进化、致病性、跨宿主传播及相关分子机制、病毒抗原变异的分子基础及抗原变异预测、高产高效流感疫苗等方向研究并取得了一系列的创新性研究成果，在 Nature Communications, PNAS, Nature Microbiology, Journal of Virology, Journal of general virology 等杂志发表 SCI 文章 15 篇，申请国际专利 5 项。先后参与科研项目 7 项，包括加拿大CIHR 项目 2 项、美国 CRIP、盖茨基金项目、WARF 项目和 ASPR 项目 4 项以及“十三五“国家重点研发计划重点专项 1 项。科研项目： 1.南京农业大学高层次引进人才启动经费 2.参与“十三五”国家重点研发计划重点专项“动物流感病毒遗传变异机理研究”2016YFD0500206 发明专利： 1. Mutations in the influenza A virus NS1 gene and use thereof. Inventors: E. G Brown, Nicole Forbes and Jihui Ping. US and Canadian Patents filed. July 10, 2010. NO.20110070254 2. High titer recombinant influenza viruses with enhanced replication in MDCK or Vero cells or Eggs. Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. US patent NO: P130287US02. Europe patent NO: P130287EU01, Janpan patent NO: P130287JP01, Australia patent NO: P130287AU01. 3. Improved influenza B viruses replication for vaccine development. Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. (In progress, Ref No: P150360WO01). 4. Improved influenza vaccines. Inventors: Yoshihiro Kawaoka, Derel Smith, Chengjun Li, Gabriele Neumann, Jihui Ping, Eileen Maher, Shufang Fan, David Burke, Ronaldus Fouchier, Ana Mosterin Hopping, Sarah L. James, Bjorn F. Koel, Samuel H. Wilks, Judith M. Fonville, Ramona Mogling (In processing). 5. Improved influenza virus replication by inhibiting microRNA Let-7C binding to influenza vRNA and mRNA. nventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. (In progress, Ref No: P150345US02).

研究领域

1.流感病毒的分子遗传进化，致病性和跨宿主传播的分子机制，抗原变异的分子机制及抗原变异预测以及流感疫苗研发。 2.野生动物病毒性疫病病原的检测和溯源研究，探讨病原在野生宿主和自然环境中的分布，建立疾病发生和扩散模型；揭示病原的流行特征、抗原变异、致病性及跨宿主传播的分子特征，评估病原对野生动物、家畜以及人类的威胁，开展相关疫苗和抗病毒药物研发。 3.非洲猪瘟、新城疫、小反刍兽疫等外来动物疫病快速诊断和疫苗开发等防控技术研究。

近期论文

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1. Jihui Ping, Tiago J. S. Lopes, Gabriele Neumann, Yoshihiro Kawaoka, Development of high-yield influenza B virus vaccine viruses, PNAS, 2016 Dec 5. pii: 201616530. 2. Chengjun Li*, Masato Hatta*, David F. Burke*, Jihui Ping*, Ying Zhang*, Makoto Ozawa, Andrew S. Taft, Subash C. Das, Anthony P. Hanson, Jiasheng Song, Masaki Imai, Peter R. Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A. Russell, Sarah L. James, Eugene Skepner, Eileen A. Maher, Gabriele Neumann, Alexander I. Klimov, Anne Kelso, John McCauley, Dayan Wang, Yuelong Shu, Masato Tashiro, Nancy J. Cox, Derek J. Smith, and Yoshihiro Kawaoka. Selection of antigenic variants representing a new cluster of pandemic (H1N1) 2009 influenza viruses. Nature Microbiology, doi: 10.1038/nmicrobiol. 2016.58 (Co-first author) 3. Jihui Ping, Tiago J. S. Lopes, Chairul A. Nidom, Elodie Ghedin, Catherine A. Macken, Adam Fitch, Masaki Imai, Eileen A. Maher, Gabriele Neumann, Yoshihiro Kawaoka. Development of high-yield influenza A virus vaccine viruses. Nature Communications. 6:8148 doi: 10.1038/ncomms9148 (2015). 4. Yuanlong Hou, Xiaoyan Wang, Zhihai Lei, Jihui Ping, jiajian Liu, Zhiyu Ma, Zheng Zhang, Cuicui Jia, Mengmeng Jin, Xiang Li, Xiaoliang Li, Shaoqiu Chen, Yingfang Lv, Yingdong Gao, Wei Jia, and Juan Su. Heat-Stress-Induced Metabolic Changes and Altered Male Reproductive Function. J Proteome Res. 2015 Mar 6;14(3):1495-503. doi: 10.1021/pr501312t. 5. Dankar SK, Miranda E, Forbes NE, Pelchat M, Tavassoli A, Selman M, Jihui Ping, Jia J, Brown EG. Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30. Virol J. 2013 Jul 25;10:243. doi: 10.1186/1743-422X-10-243. 6. Tokiko Watanabe, Maki Kiso, Satoshi Fukuyama, Noriko Nakajima, Masaki Imai, Shinya Yamada, Shin Murakami, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Yoshihiro Sakoda, Emi Takashita, Ryan McBride, Takeshi Noda, Masato Hatta, Hirotaka Imai, Dongming Zhao, Noriko Kishida, Masayuki Shirakura, Robert P. de Vries, Shintaro Shichinohe, Masatoshi Okamatsu, Tomokazu Tamura, Yuriko Tomita, Naomi Fujimoto, Kazue Goto, Hiroaki Katsura, Eiryo Kawakami, Izumi Ishikawa, Shinji Watanabe, Mutsumi Ito, Yuko Sakai-Tagawa, Yukihiko Sugita, Ryuta Uraki, Reina Yamaji, Amie J. Eisfeld, Gongxun Zhong, Shufang Fan, Jihui Ping, Eileen A. Maher, Anthony Hanson, Yuko Uchida, Takehiko Saito,Makoto Ozawa, Gabriele Neumann, Hiroshi Kida, Takato Odagiri, James C. Paulson,Hideki Hasegawa,Masato Tashiro& Yoshihiro Kawaoka Characterization of H7N9 influenza A viruses isolated from humans. Nature. 2013 Sep 26;501(7468):551-5. doi: 10.1038/nature12392. 7. Jihui Ping, Mohammed Selman, Shaun Tyler, Nicole Forbes, Liya Keleta, Earl Brown, Low pathogenic avian influenza A/Turkey/Ontario/6213/1966(H5N1) is the progenitor of highly pathogenic A/Turkey/Ontario/7732/1966(H5N9). Journal of General virology; 2012 Aug; 93 (Pt 8): 1649-57 8. Nicole E. Forbes, Jihui Ping, Samar K. Dankar, Jian-Jun Jia, Mohammed Selman, Liya Keleta, Yan Zhou, Earl G. Brown, Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse. 2012, PloS ONE, Volume 7 (2): e31839 9. Jihui Ping, L. Keleta, N. Forbes, S. Dankar, W. Stecho, S. Tyler, Y. Zhou, L. Babiuk, H. Weingartl, R. A. Halpin, A. Boyne, J. Bera, J. Hostetler, N. Fedorova, K. Proudfoot, D. Katzel, T.B. Stockwell, E. Ghedin, D. Spiro and e. G. Brown, Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse. 2011, PLoS ONE, Volume 6(6): e217403. 10. Samar K. Dankar, Shuai Wang, Jihui Ping, Nicole E. Forbes, Liya Keleta, Earl G. Brown. Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence. Virol J. 2011 Jan 12; 8(1):13 11. Jihui Ping, Samar K. Dankar, Nicole E. Forbes, Liya Keleta, Yan Zhou, Shaun Tyler Earl G. Brown, PB2 and HA Mutations are Major Determinants of Host Range and Virulence in Mouse-Adapted Influenza A Virus. Journal of virology. 2010, (84), 10606-10618. 12. Jihui Ping, Chengjun Li, Guohua Deng, Yongping Jiang, Guobin Tian, Shuxia Zhang, Zhigao Bu, Hualan Chen. Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody. Biochem. Biophys.Res. Commun. 2008, (371):168-171 13. Chengjun Li, Jihui Ping, Bo Jing, Guohua Deng, Yongping Jiang, Yanbing Li, Guobin Tian, Kangzhen Yu, Zhigao Bu, Hualan Chen. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochem. Biophys. Res. Commun. 2008, (372): 293-297 14. Juan Su, Zhihai Lei, Wenlong Zhang, Hongmei Ning, Jihui Ping. Distribution of orexin B and its relationship with GnRH in the pig hypothalamus. Research in Veterinary Science. 2008,(85): 315-323 15.Chengjun Li, Kangzhen Yu, Guobin Tian, Dandan Yu, Liling Liu, Bo Jing, Jihui Ping, Hualan Chen. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China. Virology. 2005 Sep 15;340(1):70-83.