万敏 - 中国海洋大学

个人简介

教育及工作经历 1996.09-2000.06中国海洋大学，水产养殖专业，本科 2000.09-2003.07中国海洋大学，水产养殖专业，硕士 2003.08-2004.12瑞典卡洛琳斯卡医学院，分子生物学，硕士 2005.01-2010.02瑞典卡洛琳斯卡医学院，生物医药学，博士 2010.02-2012.02瑞典卡洛琳斯卡医学院，博士后 2012.02-2017.06瑞典卡洛琳斯卡医学院，助理教授 2017.06-至今中国海洋大学水产学院，筑峰三岗教授

研究领域

水生动物营养免疫学和营养微生态学，主要研究水产动物的营养代谢、先天免疫、肠道菌群和病原菌之间的交互影响作用。

近期论文

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已发表论文到目前为止在SCI收录期刊和出版书籍中共发表论文24篇，通讯作者6篇，第一作者8篇。 1.Wan M*, Tang X, Rekha RS, Muvva SSVJR, Brighenti S, Agerberth B, Haeggström JZ.Prostaglandin E2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection.FASEB J.2018 Jan 17; doi: 10.1096/fj.201701308. [Epub ahead of print]*通讯作者 2.WanM, TangX, StsiapanavaA and HaeggströmJZ. Biosynthesis of Leukotriene B4. Semin Immunol. 2017 Oct;33:3-15. 3.Xu X, Bi D, Wan M*. Characterization and immunological evaluation of low molecular weight alginate derivatives. Curr Top Med Chem. 2016;16(8):874-87.*通讯作者 4.Wan M*,Tang X, Haeggstrom JZ. Host Defense Peptides and Their Potential as Therapeutic Agents (Edited by Richard M. Epand). Chapter 6: Host Defense Peptides and the Eicosanoid Cascade. 2016. *通讯作者 5.Tang X, Basavarajappa D, Haeggström JZ, Wan M*. P2X7receptor regulates internalization of antimicrobial peptide LL-37 by human macrophages that promotes intracellular pathogen clearance. J Immunol. 2015 Aug 1;195(3):1191-201. *通讯作者 6.Xu X, Bi D, Wu X, Wang Q, Wei G, Chi L, Jiang Z, Oda T, Wan M*. Unsaturated guluronate oligosaccharide enhances the antibacterial activities of macrophages. FASEB J. 2014 Jun;28(6):2645-2654.*通讯作者 7.Wan M, Soehnlein O, Tang X, van der Does AM, Smedler E, Uhlén P, Lindbom L, Agerberth B, and Haeggström JZ. Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. FASEB J. 2014 Aug;28(8):3456-67. 8.Wan M, Van Der Does AM, Tang X, Lindbom L, Agerberth B, Haeggström JZ. Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages. J Leukoc Biol. 2014 Jun;95(6):971-81. 9.Basavarajappaa D, Wan M, Lukica A, Steinhilber D, Samuelssona B, and Rådmarka O. Coactosin-like protein (CLP) and 5-lipoxygenase activating protein (FLAP): roles in cellular leukotriene biosynthesis. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11371-6. 10.Wan M, Godson C, Guiry PJ, Agerberth B, Haeggström JZ. Leukotriene B4/LL-37 proinflammatory circuits are mediated by BLT1 and FPRL-1, and are counter-regulated by lipoxin A4 and resolvin E1. FASEB J. 2011, 25(5):1697-705.