刘极龙 - 华南农业大学

个人简介

刘极龙，男，1982年2月出生于辽宁省丹东市宽甸县，理学博士，2002年进入东北农业大学生物科学理科基地八年制本硕博连读班，2011年博士毕业。2011年毕业后在汕头大学理学院生物系进行教学科研工作，讲师。2013年转入华南农业大学兽医学院。自2006年以来，一直从事哺乳动物胚胎着床的分子机制研究。最近5年，以第一作者或通讯作者身份发表在JBC、PLOS one、Reproductive Sciences等杂志发表SCI论文7篇，单篇引用最高为17次。学历及培训经历： 2002年09月-2011年06月东北农业大学生命科学学院 “本硕博”连读工作经历： 2013年07月—至今华南农业大学兽医学院讲师 2011年07月—2013年07月汕头大学理学院生物系讲师承担科研项目情况：主持国家自然科学基金2项： 1. 国家自然科学基金面上项目，31271602，《甲状腺激素脱碘酶DIO3在小鼠胚胎着床过程中的调节与功能》，2012/08-2016/12，88万，结题，主持 2. 国家自然科学基金面上项目，31771665，《XIST基因在小鼠子宫衰老过程中的作用和机制研究》，2018/01-2021/12，58万，在研，主持参与国家自然科学基金6项： 1. 国家自然科学基金青年项目，31501206，《Snail在着床、内膜重建、异位症中的功能及作用机制》，2015/08-2018/12, 20万元, 在研，参与 2. 国家自然科学基金面上项目，31572475，《microRNA在两性胸腺差异性退化中的作用及其基因调控网络研究》，2015/08-2019/12，76.8万元，在研，参与 3. 国家自然科学基金面上项目，31471397，《胚胎着床和蜕膜化过程中多胺的调节及功能》，2014/08- 2018/12，85万元，在研，参与 4. 国家自然科学基金面上项目，31272263，《小鼠子宫中谷胱甘肽过氧化物酶3（GPX3）的调节及其与蜕膜化的关系》，2012/08-2016/12，90万，结题，参与 6. 国家自然科学基金重点项目，30930013，《小鼠胚胎着床过程中信号转导和转录激活因子3的作用机理》，2010/01-2013/12，191万，结题，参与写给学生的话：导师易作，有胸怀肯担当足矣，哪怕庸而不昏；学生难为，有本领有豪情不够，仍需下笨功夫。

研究领域

·生殖生物学：筛选子宫对胚胎着床接受性相关的分子标记，以及研究胚胎着床和子宫蜕膜化的分子机理。 ·生物信息学：通过基因芯片、蛋白组学、大规模并行测序等高通量方法并结合开发新的生物信息学算法、软件和数据库来研究胚胎着床过程。 ·非编码RNA：主要兴趣在于研究非编码RNA的功能及作用机理

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

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Peng, Y.S. Fu, Identification of gene expression changes in rabbit uterus during embryo implantation, Genomics, 107 (2016) 216-221. [7] J.L. Liu*, M. Zhao, Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network Analysis, International journal of molecular sciences, 17 (2016). [8] J.L. Liu*, M. Zhao, A PubMed-wide study of endometriosis, Genomics, 108 (2016) 151-157. [9] J.L. Liu*, T.S. Wang, M. Zhao, Genome-Wide Association Mapping for Female Infertility in Inbred Mice, G3 (Bethesda, Md.), 6 (2016) 2929-2935. [10] X.H. Liang, W.B. Deng, Y.F. Liu, Y.X. Liang, Z.M. Fan, X.W. Gu, J.L. Liu, A.G. Sha, H.L. Diao, Z.M. Yang, Non-coding RNA LINC00473 mediates decidualization of human endometrial stromal cells in response to cAMP signaling, Scientific reports, 6 (2016) 22744. [11] R.J. Zuo, X.W. Gu, Q.R. Qi, T.S. Wang, X.Y. Zhao, J.L. Liu, Z.M. Yang, Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy, The Journal of biological chemistry, 290 (2015) 21280-21291. [12] T.S. Wang, F. Gao, Q.R. Qi, F.N. Qin, R.J. Zuo, Z.L. Li, J.L. Liu, Z.M. Yang, Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model, Biology open, 4 (2015) 893-902. [13] Q.R. Qi, X.Y. Zhao, R.J. Zuo, T.S. Wang, X.W. Gu, J.L. Liu, Z.M. Yang, Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization, Cell cycle (Georgetown, Tex.), 14 (2015) 1842-1858. [14] J.L. Liu*, T.S. Wang, M. Zhao, Y. Peng, Y.S. Fu, A Transcriptomic Study of Maternal Thyroid Adaptation to Pregnancy in Rats, International journal of molecular sciences, 16 (2015) 27339-27349. [15] J.L. Liu*, T.S. Wang, Systematic Analysis of the Molecular Mechanism Underlying Decidualization Using a Text Mining Approach, PloS one, 10 (2015) e0134585. [16] J.L. Liu*, Y. Peng, Y.S. Fu, Efficient prediction of progesterone receptor interactome using a support vector machine model, International journal of molecular sciences, 16 (2015) 4774-4785. [17] W.B. Deng, X.H. Liang, J.L. Liu, Z.M. Yang, Regulation and function of deiodinases during decidualization in female mice, Endocrinology, 155 (2014) 2704-2717. [18] R.W. Su, B. Jia, H. Ni, W. Lei, S.L. Yue, X.H. Feng, W.B. Deng, J.L. Liu, Z.A. Zhao, T.S. Wang, Z.M. Yang, Junctional adhesion molecule 2 mediates the interaction between hatched blastocyst and luminal epithelium: induction by progesterone and LIF, PloS one, 7 (2012) e34325. [19] J.L. Liu, X.H. Liang, R.W. Su, W. Lei, B. Jia, X.H. Feng, Z.X. Li, Z.M. Yang, Combined analysis of microRNome and 3'-UTRome reveals a species-specific regulation of progesterone receptor expression in the endometrium of rhesus monkey, The Journal of biological chemistry, 287 (2012) 13899-13910. [20] W. Lei, X.H. Feng, W.B. Deng, H. Ni, Z.R. Zhang, B. Jia, X.L. Yang, T.S. Wang, J.L. Liu, R.W. Su, X.H. Liang, Q.R. Qi, Z.M. Yang, Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice, The Journal of biological chemistry, 287 (2012) 15174-15192. [21] A.G. Sha, J.L. Liu, X.M. Jiang, J.Z. Ren, C.H. Ma, W. Lei, R.W. Su, Z.M. Yang, Genome-wide identification of micro-ribonucleic acids associated with human endometrial receptivity in natural and stimulated cycles by deep sequencing, Fertility and sterility, 96 (2011) 150-155.e155. [22] J.L. Liu, Z.M. Yang, Non-coding RNAs and embryo implantation, Frontiers in bioscience (Elite edition), 3 (2011) 1092-1099. [23] J.L. Liu, R.W. Su, Z.M. Yang, Differential expression profiles of mRNAs, miRNAs and proteins during embryo implantation, Frontiers in bioscience (Scholar edition), 3 (2011) 1511-1519. [24] R.W. Su, W. Lei, J.L. Liu, Z.R. Zhang, B. Jia, X.H. Feng, G. Ren, S.J. Hu, Z.M. Yang, The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation, PloS one, 5 (2010) e15513. [25] Y.C. Zhao, Y.J. Chi, Y.S. Yu, J.L. Liu, R.W. Su, X.H. Ma, C.H. Shan, Z.M. Yang, Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period, Endocrinology, 149 (2008) 2325-2332. [26] S.J. Hu, G. Ren, J.L. Liu, Z.A. Zhao, Y.S. Yu, R.W. Su, X.H. Ma, H. Ni, W. Lei, Z.M. Yang, MicroRNA expression and regulation in mouse uterus during embryo implantation, The Journal of biological chemistry, 283 (2008) 23473-23484. [27] X.H. Ma, S.J. Hu, H. Ni, Y.C. Zhao, Z. Tian, J.L. Liu, G. Ren, X.H. Liang, H. Yu, P. Wan, Z.M. Yang, Serial analysis of gene expression in mouse uterus at the implantation site, The Journal of biological chemistry, 281 (2006) 9351-9360.