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个人简介

先后主持973项目课题1项,国家自然科学基金3项,其他国家级与省部级项目20余项。发表论文221篇,其中SCI论文31篇,获国家科技进步二等奖1项,省科学技术一等奖2项,省级教学成果一等奖2项,其它省级科技成果奖6项,厅局级8项,获发明专利授权9件,获南粤优秀教师。 工作经历 1991,7--至今 华南农业大学动物科学学院从事《动物繁殖学》教学、科研、技术推广工作。 教育经历 1984,9-1988,7 中国农业大学动物科学学院动物科学专业本科,获得学士学位 1988,9-1991,7 中国农业大学动物科学学院动物繁殖专业硕士研究生,获得硕士学位 2002,1-2003,2 美国康涅狄格大学动物科学系访问学者 2000,9-2003,7 华南农业大学动物科学学院动物营养与饲料科学专业博士研究生,获得博士学位 获奖、荣誉称号 获国家科技进步二等奖1项、广东省科学技术一等奖2项,广东省级教学成果一等奖2项,其它省级科技成果奖6项,厅局级8项,获南粤优秀教师。 科研项目 主持国家、省部级课题30余项。 出版专著和教材 出版专著和教材12部。科研创新 获得授权发明专利9件。 教学活动 主讲《动物繁殖学》、《动物繁殖新技术》、《动物细胞工程》等课程。 指导学生情况 指导博士研究生14名,硕士研究生67名。 我的团队 1、卫恒习副研究员 2、孟立博士 3、李莉高级实验师

研究领域

动物胚胎工程、种猪繁殖技术、种猪生产管理等。

卵母细胞体外成熟、精原干细胞、胚胎干细胞和转基因动物;印记基因及其对种猪繁殖性能的影响;现代养猪人工授精技术、批次化生产、公猪受精能力及繁殖障碍克服。

近期论文

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Li Meng, Katja Teerds, Jian Tao, Hengxi Wei, Marcel Jaklofsky, Zhihong Zhao, Yaodi Liang, Li Li, Chi Chiu Wang and Shouquan Zhang*. Characteristics of Circular RNA Expression Profiles of Porcine Granulosa Cells in Healthy and Atretic Antral Follicles. International Journal of Molecular Sciences. 2020, 21, 5217; doi:10.3390/ijms21155217 Feng Cong, Fanwen Zeng, Miaoli Wu, JingjingWang, Bihong Huang, Yingying Wang, QingWang, Shouquan Zhang, Lei Ma, Pengju Guo, Weiwei Zeng. Development of a real-time reverse transcription recombinase polymerase amplification assay for rapid detection of spring viremia of carp virus. Molecular and Cellular Probes. 2020,50:101494. doi: 10.1016/j.mcp.2019.101494. Kai Wang, Yun Chen, DeLong Zhang, RongGen Wang, ZhiHong Zhao, MeiYing Feng, HengXi Wei, Li Li, Shouquan Zhang*. Effects of 25-hydroxycholecalciferol supplementation in maternal diets on reproductive performance and the expression of genes that regulate lactation in sows. Animal Science Journal. 2020, DOI: 10.1111/asj.13391 Yuming Chen, Hengxi Wei, Yanting Liu, Fenglei Gao, Zhilin Chen, Ping Wang, Li Li, Shouquan Zhang*. Identification of new protein biomarkers associated with the boar fertility using iTRAQ-based quantitative proteomic analysis. International Journal of Biological Macromolecules. 2020, 162:50-59 Yun Chen, Kai Wang, Delong Zhang, Zhihong Zhao, Jianhao Huang, Lele Zhou, Meiying Feng, Junsong Shi, Hengxi Wei, Li Li, Zhenfang Wu, Shouquan Zhang*. GPx6 is involved in the in vitro induced capacitation and acrosome reaction in porcine sperm. Theriogenology. 2020, 156: 107-115 Fanwen Zeng, Miaoli Wu, Lei Ma, Zongxi Han, Yue Shi, Yanping Zhanga , Changjun Liu, Shouquan Zhang∗, Feng Cong, Shengwang Liu. Rapid and sensitive real-time recombinase polymerase amplification for detection of Marek's disease virus. Molecular and Cellular Probes. 2019, 48 :101468 Shan-Shan Liu, Eithne Margaret Maguire, Yin-Shan Bai, Li Huang, Yurong Liu, Liping Xu, Iliana Fauzi, Shouquan Zhang, Qingzhong Xiao, Ning-Fang Ma. A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties. Molecular and Cellular Biology. 2019, 39(4): e00357-18 Kai Wang, Yun Chen, Zhihong Zhao, Meiying Feng, Shouquan Zhang*. Identification of potential core genes and miRNAs in testicular seminoma via bioinformatics analysis. Molecular Medicine Reports. 2019, 20: 4013-4022 Meiying Feng, Nannan Dang, Yinshan Bai, Hengxi Wei, Li Meng, Kai Wang, Zhihong Zhao, Yun Chen, Fenglei Gao, Zhilin Chen, Li Li, Shouquan Zhang*. Differential expression profiles of long non coding RNAs during the mouse pronuclear stage under normal gravity and simulated microgravity. Molecular Medicine Reports. 2019, 19: 155-164. Lina Xiao, Ziran Wu, Junzhe Zhang, Guohua Wang, Yuhui Ma, Yayun Ding, Xiao He, Shouquan Zhang∗, and Zhiyong Zhang. Synthesis, Photothermal Effect and Cytotoxicity of Fe3O4@Au Nanocomposites. Journal of Nanoscience and Nanotechnology. 2019, 19(5):2467-2473 Yinshan Bai, Cui Zhu, Meiying Feng, Hengxi Wei, Li Li, Xiuchun Tian, Zhihong Zhao, Shanshan Liu, Ningfang Ma, Xianwei Zhang, Ruyi Shi, Chao Fu, Zhenfang Wu and Shouquan Zhang*, Previously claimed male germline stem cells from porcine testis are actually progenitor Leydig cells. Stem Cell Research & Therapy. 2018, 9:200 Guoqian Liu, Kai Liu, Hengxi Wei, Li Li, and Shouquan Zhang*, Generation of porcine fetal fibroblasts expressing thetetracycline-inducible Cas9 gene by somatic cell nuclear transfer. Molecular Medicine Reports, 2016, 14(3): 2527-2533 Yinshan Bai, Meiying Feng, Shanshan Liu, Hengxi Wei, Li Li, Xianwei Zhang, Chao Shen, Shouquan Zhang* and Ningfang Ma, Differential gene expression in mouse spermatogonial stem cells and embryonic stem cells. International Journal of Molecular Medicine, 2016, 38(2): 423-432 Hengxi Wei, Xiangjie Liu, Jihong Yuan, Li Li, Dongdong Zhang, Xinzheng Guo, Lin Liu, and Shouquan Zhang*. Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis. BioMed Research International. 2015. doi:10.1155/2015/625192. Ruyi Shi, Yinshan Bai, Shengpu Li, Hengxi Wei, Xiujuan Zhang, Li Li, X Cindy Tian, Qingyan Jiang, Chong Wang, Lili Qin, Jiye Cai, Shouquan Zhang*, Characteristics of Spermatogonial Stem Cells derived from neonatal porcine testis. Andrologia, 2015, 47:765-778 Minhua Hu, Zhihong Zhao, Liqi Duanmu, Hengxi Wei, Fenglei Gao, Li Li, Jun Ying, Shouquan Zhang*, Analysis of Imprinted Gene Expression and Implantation in Haploid Androgenetic Mouse Embryos. Andrologia, 2015, 47:102-108 Minhua Hu, Li-Chi TuanMu, Hengxi Wei, Fenglei Gao, Li Li, Shouquan Zhang*, Development and imprinted gene expression in uniparental preimplantation mouse embryos in vitro. Molecular Biology Reports. 2015, 42(2): 345-353 Xiujuan Zhang, Li Li, Yinshan Bai, Ruyi Shi, Hengxi Wei, Shouquan Zhang*, Mouse Undifferentiated Spermatogonial Stem Cells Cultured as Aggregates under Simulated Microgravity. Andrologia, 2014, 46:1013-1021 Minhua Hu, Hengxi Wei, Jingfeng Zhang, Yinshan Bai, Fenglei Gao, Li Li and Shouquan Zhang*. Efficient production of chimeric mice from embryonic stem cells injected into 4- to 8-cell and blastocyst embryos. Journal of Animal Science and Biotechnology, 2013, 4(4):264-270. doi:10.1186/2049-1891-4-12. Yu K, Shu G, Yuan F, Zhu X, Gao P, Wang S, Wang L, Xi Q, Zhang S, Zhang Y, Li Y, Wu T, Yuan L, Jiang Q. Fatty Acid and Transcriptome Profiling of Longissimus Dorsi Muscles between Pig Breeds Differing in Meat Quality. International Journal of Biological Sciences. 2013; 9(1):108-118. Li Z, Shi J, Liu D, Zhou R, Zeng H, Zhou X, Mai R, Zeng S, Luo L, Yu W, Zhang S, Wu Z. Effects of Donor Fibroblast Cell Type and Transferred Cloned Embryo Number on the Efficiency of Pig Cloning. Cell Reprogram. 2012,15(1):35-42. Zhang Jingfeng, Wei Hengxi, Guo Xinzheng, Hu Minhua, Gao Fenglei, Li Li, Zhang Shouquan*. Functional verification of the diphtheria toxin A gene in a recombinant system. Journal of Animal Science and Biotechnology. 2012, 3(1):29;DOI: 10.1186/2049-1891-3-29 Shengpu Lia,Ruyi Shi,Qiulan Wang,Jiye Cai,Shouquan Zhang. Nanostructure and β1-integrin distribution analysis of pig's spermatogonial stem cell by atomic force microscopy. Gene. 2012, 495(6): 189-193 Changli Wu, Xinzheng Guo, Fang Wang, Xiaoshuang Li, X. Cindy Tian, Li Li, Zhenfang Wu, Shouquan Zhang *. Simulated Microgravity Compromises Mouse Oocyte Maturation by Disrupting Meiotic Spindle Organization and Inducing Cytoplasmic Blebbing. PLoS ONE, 2011, 6(7): e22214 Shengping Hou, Yuming Chen, Jie Liang, Li Li, Tongshan Wu, X.Cindy Tian, Shouquan Zhang*. Developmental Stage-Specific Imprinting of IPL in Domestic Pigs (Sus scrofa). Journal of Biomedicine and Biotechnology. 2010, doi:10.1155/2010/527539 Carol Lynn Curchoea, Shouquan Zhang, Lan Yang, Raymond Pagec, X. Cindy Tian. Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle. Animal Reproduction Science, 2009, 116(3-4): 213-215 Chao Li, Yanfang Bin, Carol Curchoe, Lan Yang, Dingyuan Feng, Qingyan Jiang, Michael O'Neill, X. Cindy Tian, Shouquan Zhang*. Genetic Imprinting of H19 and IGF2 in Domestic Pigs (Sus scrofa). Animal Biotechnology, 2008, 19(1): 22-27 Tian XC, Smith SL, Zhang SQ, Kubota C, Curchoe C, Xue F, Yang L, Du F, Sung LY, Yang X. Nuclear reprogramming by somatic cell nuclear transfer--the cattle story. Society of Reproduction and Fertility supplement. 2007; 64:327-339 Carol Curchoe*,Shouquan Zhang*, Yanfang Bin, Xiquan Zhang, Lan Yang, Dingyuan Feng, Michael O'Neill and X. Cindy Tian. Promoter-Specific Expression of the Imprinted IGF2 Gene in Cattle (Bos taurus). Biology of Reproduction. 2005, 73(6): 1275-1281. (*:These authors contributed equally to this work.) Carol Curchoe, Shouquan Zhang, Yanfang Bin, Lan Yang, and X. Cindy Tian. Promoter-specific expression of the imprinted igf2 gene in cattle. Reproduction, Fertility and Development. 2005, 17(1):259. Shouquan Zhang, Chikara Kubota, Lan Yang, Yuqin Zhang, Raymond Page, Michael O’Neill, Xiangzhong Yang, and X. Cindy Tian. Genomic imprinting of H19 in naturally reproduced and cloned cattle. Biology of Reproduction. 2004, 71(5): 1540-1544 Wang Chong,Shouquan Zhang*,Yang Guan-Fu,Glucose metabolism during Kunming mouse preimplantation development: analysis of gene transcription in embryos in vivo,Zoological Research,2001,22(4):340-344

学术兼职

国家生猪种业工程技术研究中心副主任,中国畜牧兽医学会动物繁殖学分会副理事长,全国母猪定时输精技术开发与产业化应用协助组副组长,中国农业生物技术学会动物生物技术分会常务理事,广东省现代农业产业体系生猪创新团队育种与繁育岗位专家,广东省养猪协会专家委员会专家等。

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