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个人简介

1998,09-2002,07 东北师范大学 化学专业学士 2002,09-2005,07 东北师范大学 分析化学专业硕士 2005,09-2008,08 全北国立大学(韩国) 高分子纳米工学科 博士 2008,08-2009,08 全北国立大学(韩国) Polymer BIN Fusion Research Center 博士后 2009,12-2012,02 北京科技大学 材料科学与工程学院 讲师 2012,03-2014,03 国家纳米科学中心 纳米生物与安全效应实验室 助理研究员 2014,03-2017,03 国家纳米科学中心 纳米生物与安全效应实验室 副研究员 2017,03-现在 国家纳米科学中心 纳米生物与安全效应实验室 特聘研究员 2017,09-2018,02 加州大学戴维斯分校 医学院 访问学者

研究领域

基础 过程仿生(病/生理条件下微纳结构的组装、转化及其生物学效应) 1.微纳结构分子构筑基元的开发(组装、靶向多肽筛选;双芘荧光染料开发) 2.分子间相互作用、组装结构和形貌的调控 3.“在体”纳米结构的表征技术联合 4.仿生细胞外基质形成过程、凝血过程、人类防御素-6抑菌过程等配受体相互作用诱导自放大组装的研究 5.仿生自噬、分子伴侣蛋白等动态共组装过程的研究等 应用 1.基于细胞外基质仿生的纳米多肽网络抗体用于肿瘤诊疗、眼底病治疗 2.基于人类防御素-6仿生的纳米多肽网络抗体用于病原体诊疗 3.基于模拟自噬过程的自毁灭纳米清道夫用于神经退行性疾病的治疗 4.基于细胞外基质仿生的纳米多肽网络用于组织再生。 5.纳米抗菌材料用于骨内植物抗感染,结核治疗;导尿管抗感染;抗菌涂料等 6.眼科纳米材料,用于后发性白内障的防治,青光眼等;手术辅助医疗器械等 7.液晶材料的开发与制备,主要用于药物释放、生物检测、环境、农业领域等

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Lu Zhang#, Di Jing#, Nian Jiang, Tatu Rojalin, Christopher Michael Baehr, Dalin Zhang, Wenwu Xiao, Yi Wu, Zhaoqing Cong, Jian Jian Li, Yuanpei Li, Lei Wang* and Kit S Lam*, Transformable Peptide Nanoparticles Arrest Her2 Signaling and Cause Cancer Cell Death In Vivo, Nature Nanotech., 2020, 15, 145–153. Pei-Pei Yang#, Kuo Zhang#, Ping-Ping He, Yu Fan, Zi-Ming Chen, Da-Yong Hou, Yuan Li, Yu Yi, Dong-Bing Cheng, Jing-Ping Zhang, Lei Wang,* and Hao Wang*, A Biomimetic Platelet Based on Assembling Peptides Initiates Artificial Coagulation, Accepted, Sci. Adv., 2020, aaz4107. Yu Fan#, Xiang-Dan Li#, Ping-Ping He, Xiao-Xue Hu, Kuo Zhang, Jia-Qi Fan, Pei-Pei Yang, Hao-Yan Zheng, Wen Tian, Zi-Ming Chen, Lei Ji, Hao Wang and Lei Wang*, A Biomimic Peptide Recognizes and Traps Bacteria In Vivo as Human Defensin-6, Accepted, Sci. Adv, 2020, aaz4767. Jia-Qi Fan, Yu Fan, Zi-Jin Wei, Yi-Jing Li, Xiang-Dan Li,* Lei Wang,* and Hao Wang* Targeting N-Cadherin through Transformable Peptide Nanoparticles to Inhibit the Migration and Adhesion of Cancer Cells, Accepted, Chin. Chem. Lett., 2020, CCLET-D-20-00437. Zi-Ming Chen, Kuo Zhang, Jia-Qi Fan, Yu Fan, Chao Yang, Wen Tian, Yuan Li, Wen-Liang Li, Jing-Ping Zhang, Hao Wang and Lei Wang,* In Situ Construction of Ligand Nano-Network to Integrin αvβ3 for Angiogenesis Inhibition, Accepted, Chin. Chem. Lett., 2020, CCLET-D-20-00327. Ping-Ping He, Xiang-Dan Li*, Lei Wang* and Hao Wang*, Bispyrene-Based Self-Assembled Nanomaterials: In Vivo Self-Assembly, Transformation, and Biomedical Effects, Acc. Chem. Res., 2019, 52(2), 367-378. Li-Li Li, Zeng-Ying Qiao*, Lei Wang* and Hao Wang,* Programmable Construction of Peptide-Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics, Adv. Mater., 2019, 1804971. Yang Yang#, Lei Wang#, Hongqian Cao, Mingjuan Han, Yue Li, Hao Wang*, Bingbing Sun and Junbai Li*, Photodynamic Therapy with Liposomes Encapsulating Photosensitizers with Aggregation-Induced Emission, Nano Lett., 2019, 19(3), 1821-1826. Qiang Luo,# Yao-Xin Lin,# Pei-Pei Yang,# Yi Wang, Guo-Bin Qi, Zeng-Ying Qiao, Bing-Nan Li, Kuo Zhang, Jing-Ping Zhang,* Lei Wang* and Hao Wang*, A Self-destructive Nanosweeper that Captures and Clears Amyloid β-Peptides, Nature Commun., 2018, 9, 1802. Guo-Bin Qi#, Yu-Juan Gao#, Lei Wang* and Hao Wang*, Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy, Adv. Mater., 2018, 30(22), 1703444. Pei-Pei Yang, Chao Yang, Kuo Zhang, Lei Wang,* and Hao Wang* KLVFF Peptide Functionalized Nanoparticles Capture Aβ42 by Co-Assembly for Decreasing Cytotoxicity, Chin. Chem. Lett., 2018, 29(12), 1811-1814. Zhaozhong Li, Yang Li, Dong Wang, Qing Cui, Zhengqiang Li, Lei Wang* and Huai Yang*, Unique Fluorescence Properties of A Self-Assembling Bis-Pyrene Molecule, Chin. Chem. Lett., 2018, 29(11), 1645-1647. Chao-Xi Zhou,# Litao Li,# Yi-Guang Ma,# Bing-Nan Li, Guang Li, Zhihang Zhou, Feng Shi, Jie Weng, Cong Zhang, Fenghua Wang, Xu Cui*, Lei Wang* and Hao Wang*, A Bioactive Implant In Situ and Long-Term Releases Combined Drugs for Treatment of Osteoarticular Tuberculosis, Biomaterials, 2018, 176, 50–59. Yao-Xin Lin, Xue-Feng Hu, Yang Zhao, Yu-Juan Gao, Chao Yang, Sheng-Lin Qiao, Jiao Yan, Pei-Pei Yang, Qian Zeng, Zeng-Ying Qiao, Li-Li Li, Jiang-Bing Xie, Si-Quan Zhu, Xiao-Chun Wu, Lei Wang* and Hao Wang*, Intraocular Lens with Amorphous Nanostructured Rim for High-Efficient Eye-Disease Treatment, Adv. Mater., 2017, 29(34), 1701617. Pei-Pei Yang, Qiang Luo, Guo-Bin Qi, Yu-Juan Gao, Bing-Nan Li, Jing-Ping Zhang, Lei Wang*, and Hao Wang*, Host Materials Transformable in Tumor Microenvironment for Homing Theranostics, Adv. Mater. 2017, 29, 1605869. Yao-Xin Lin, Sheng-Lin Qiao, Yi Wang, Ruo-Xin Zhang, Hong-Wei An, Zeng-Ying Qiao, Lei Wang,* and Hao Wang* An In Situ Intracellular Self-Assembly Strategy for Quantitative and Temporal Monitoring Autophagy, ACS Nano, 2017, 11 (2), 1826–1839. Xiao-Xue Hu, Guo-Bin Qi, Yu-Juan Gao, Yao-Xin Lin, Chao Yang, Pei-Pei Yang, Hong-Xun Hao*, Lei Wang*,and Hao Wang*, Artificial Extracellular Matrix Based on Transformable Nanomaterials for High-Efficient Inhibition of Tumor Invasion and Metastasis, ACS Nano, 2017, 11 (4), 4086–4096. Kuo Zhang, Pei-Pei Yang, Jing-Ping Zhang,* Lei Wang* and Hao Wang*, Recent Advances of Transformable Nanoparticles for Theranostics, Chin. Chem. Lett., 2017, 28(9), 1808-1816.

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