个人简介
教育背景
2004-09--2009-06 中国科学院生物物理研究所 博士
2000-09--2004-06 武汉大学生命科学学院生物学基地班 学士
工作简历
2020-01~现在, 中国科学院生物物理研究所, 研究员
2012-01~2019-12,中国科学院生物物理研究所, 副研究员
2009-07~2011-12,中国科学院生物物理研究所, 助理研究员
2004-09~2009-06,中国科学院生物物理研究所, 博士
2000-09~2004-06,武汉大学生命科学学院生物学基地班, 学士
社会兼职
2016-01-01-2019-12-31,中国科学院青年创新促进会会员
2015-01-01-今,中国生理学会应激生理学专业委员会委员
近期论文
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Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner, Redox Biology, 2020, 通讯作者
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities and pathophysiological functions, BioEssays, 2020, 通讯作者
S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, Journal of Biological Chemistry, 2020, 第 8 作者
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, The EMBO Journal, 2020, 通讯作者
DJ-1 is dispensable for human stem cell homeostasis, Protein & Cell, 2019, 第 6 作者
The b′ domain of protein disulfide isomerase cooperates with the a and a′ domains to functionally interact with platelet αIIbβ3, Journal of Thrombosis and Haemostasis, 2019, 第 3 作者
AtERO1 and AtERO2 exhibit differences in catalyzing oxidative protein folding in the ER, Plant Physiology, 2019, 通讯作者
Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer, EBioMedicine, 2019, 通讯作者
Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis, Redox Biology, 2019, 通讯作者
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7, Aging Cell, 2018, 通讯作者
Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α, The EMBO Journal, 2018, 通讯作者
Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity, Journal of Biological Chemistry, 2018, 通讯作者
Characterization of the oxidative protein folding activity of a unique plant oxidoreductase, Arabidopsis protein disulfide isomerase-11, Biochemical and Biophysical Research Communications, 2018, 通讯作者
Novel roles of the non-catalytic elements of yeast protein-disulfide isomerase in its interplay with endoplasmic reticulum oxidoreductin 1, Journal of Biological Chemistry, 2016, 通讯作者
Protein disulfide–isomerase, a folding catalyst and a redox-regulated chaperone, Free Radical Biology and Medicine, 2015, 第 1 作者
Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α), Journal of Biological Chemistry, 2014, 通讯作者
Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding, Antioxidants & Redox Signaling, 2014, 第 1 作者
The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation, Biochemical Journal, 2011, 第 1 作者
Reconstitution of Human Ero1-Lα/Protein-Disulfide Isomerase Oxidative Folding Pathway in Vitro POSITION-DEPENDENT DIFFERENCES IN ROLE BETWEEN THE a AND a′ DOMAINS OF PROTEIN-DISULFIDE ISOMERASE, Journal of Biological Chemistry, 2009, 第 1 作者
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