Webb, Simon - The University of Manchester

个人简介

1990-1994: B.Sc. and MSc Chemistry, Auckland University, New Zealand (MSc with Assoc. Prof. L.J. Wright). 1994-1997: PhD, University of Cambridge, UK. (with Prof. J.K.M. Sanders FRS). 1998-1999: PDRA, University of Nijmegen, The Netherlands (with Prof. R.J.M. Nolte). 1999-2002: PDRA, Sheffield University, Sheffield, U.K. (with Profs N.H. Williams and C.A. Hunter FRS) 2002-present:Senior Lecturer in Organic Chemistry, School of Chemistry, University of Manchester.

研究领域

We use molecular self-assembly to create materials that mimic biological membranes and improve our understanding of important biological processes. Current research themes include: elucidating the role of 'cooperativity' during the binding of multivalent ligands to phospholipid bilayers; understanding the role of 'lipid rafts' in cellular recognition and reactivity; creating synthetic ion channels; using magnetic nanoparticle-vesicle assemblies to create magnetically-responsive biomaterials for cell culture; using synthetic peptides as transmembrane information relays. Descriptions of some ongoing projects are given below. For further information on the group and our research, please visit: www.webblab.org Membrane Recognition and Reactivity: We aim to quantify the effect of lipid rafts on the multivalent recognition of external ligands and the reactivity of soluble enzymes. We have shown that patches of synthetic lipids can strengthen multivalent molecular recognition and enhance enzyme reactivity. Nonetheless, any enhancement of multivalent recognition/enzyme reactivity depends upon ligand/enzyme geometry and the strength of the interaction between the ligand and membrane-bound receptors. See: J. Am. Chem. Soc. 2012, 134, 13010-13017. Membrane Communication: Controlled communication between cells is vital for a host of biological processes, and two key methods used by cells to communicate are the transport of ions across the membrane or conformational/positional changes in membrane proteins. To replicate the former, we are developing synthetic ion channels which can be opened and closed by external stimuli. To understand the latter, we aim to use external ligands to induce conformation change in membrane-spanning peptides, producing signals that are transmitted across bilayers and initiate a cascade of enzymatic transformations. See:Nature Chem. 2013, 5, 853-860. Bionanotechnology and Biomaterials: The interface between nanotechnology and biological chemistry promises to be an exciting area for future research. We have developed magnetic nanoparticle-vesicle assemblies (MNPVs) for the magnetically triggered delivery of biochemicals to cells. MNPVs consist of 800 nm vesicles containing stored drugs that are crosslinked by 10 nm superparamagnetic magnetic nanoparticles. The nanoparticles fulfil two critical roles: (a) they allow magnetic separation of MNPVs and objects linked to them; (b) they allow non-destructive release of the vesicle contents by a 400 kHz alternating magnetic field (AMF). See: Angew. Chem. Intl. Ed. Engl. 2011, 50, 12290-12293.

近期论文

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Pike, S.J.; Boddaert, T.; Raftery, J.; Webb, S.J.; Clayden, J. Participation of Non-Aminoisobutyric Acid (Aib) Residues in the 310 Helical Conformation of Aib-Rich Foldamers: A Solid State Study. New Journal of Chemistry. 2015; eScholarID:261369 | DOI:10.1039/c4nj01547a Booth, A.; Pintre, I.C.; Y. Lin, Y.; Gough J.; Webb, S.J. Release of proteins and enzymes from vesicular compartments by alternating magnetic fields. Physical Chemistry Chemical Physics. 2015; eScholarID:261457 | DOI:10.1039/C4CP05872K Coxon, T.; Almond, A.; Gough, J.E.; Webb, S.J. Catechol-hydrazone conjugates for the rapid functionalization of magnetite nanoparticles with cell targeting groups. Materials Research Society Symposium Proceedings. 2014; 1688: eScholarID:238331 | DOI:10.1557/opl.2014.433 Pike, S.J.; Raftery, J.; Webb, S.J.; Clayden, J. Conformational analysis of helical aminoisobutyric acid (Aib) oligomers bearing C-terminal ester Schellman motifs. Organic & Biomolecular Chemistry. 2014; 12: 4124-4131. eScholarID:238330 | DOI:10.1039/c4ob00268g Pike, S.J.; Diemer, V.; Raftery, J.; Webb, S.J.; Clayden, J. Designing Foldamer-Foldamer Interactions in Solution: The Roles of Helix Length and Terminus Functionality in Promoting the Self-Association of Aminoisobutyric Acid Oligomers. Chemistry: A European Journal. 2014; 20: 15981-15990. eScholarID:238334 | DOI:10.1002/chem.201403626 Brown, J.R.D.; Pintre, I.C.; Webb, S.J. Fructose controlled ionophoric activity of a cholate–boronic acid. Organic & Biomolecular Chemistry. 2014 February; (12): 2576-2583. eScholarID:221770 | DOI:10.1039/C4OB00165F Noble, GT; Craven, FL; Segarra-Maset, MD; Reyes Martínez, JE; Šardzík, R; Flitsch, SL; Webb, SJ. Sialylation of lactosyl lipids in membrane microdomains by T. cruzi trans-sialidase. Organic & Biomolecular Chemistry. 2014; 12: 9272-9278. eScholarID:238338 Booth, A.; Coxon, T.; Gough, J.E.; Webb, S.J. Targeting of a magnetic bionanomaterial to HepG2 human hepatocellular carcinoma cells using a galactose terminated lipid. Materials Research Society Symposium Proceedings. 2014; 1688: eScholarID:238332 | DOI:10.1557/opl.2014.517 Pintre, I.C.; Webb, S.J. Binding and Reactivity at Bilayer Membranes. Adv. Phys. Org. Chem. 2013 November; 47: 129-183. eScholarID:214117 Pike S.J.; De Poli, M.; Zawodny, W.; Raftery, J.; Webb, S.J.; Clayden, J. Diastereotopic fluorine substituents as 19F NMR probes of screw-sense preference in helical foldamers. Org. Biomol. Chem. 2013; 11: 3168-3176. eScholarID:194739 | DOI:10.1039/C3OB40463C Brown, R.A.; Diemer, V.; Webb, S.J.; Clayden, J. End-to-end conformational communication through a synthetic purinergic receptor by ligand-induced helicity switching. Nature Chemistry. 2013; 5(10): 853-860. eScholarID:208129 | DOI:10.1038/nchem.1747 Lin, I-H.; Birchall, L.S.; Hodson, N.; Ulijn, R.V.; Webb, S.J. Interfacing biodegradable molecular hydrogels with liquid crystals. Soft Matter. 2013; 9: 1188-1193. eScholarID:194735 | DOI:10.1039/C2SM27160E de Cogan, F.; A. Booth, A.; Gough, J.E.; Webb, S.J. Spatially-controlled apoptosis induced by released nickel(II) within a magnetically responsive nanostructured biomaterial. Soft Matter. 2013; 9: 2245-2253. eScholarID:194738 | DOI:10.1039/C2SM27379A Webb S.J. Supramolecular approaches to combining membrane transport with adhesion. Acc. Chem. Res. 2013; eScholarID:208127 | DOI:10.1021/ar400032c Gavin T. Noble , Faye L. Craven, Josef Voglmeir, Robert Šardzík, Sabine L. Flitsch, and Simon J. Webb. Accelerated Enzymatic Galactosylation of N-Acetylglucosaminolipids in Lipid Microdomains. J. Am. Chem. Soc. 2012 July; 134(31): 13010-13017. eScholarID:175626 | DOI:10.1021/ja302506t Meghan Hughes, Pim W. J. M. Frederix, Jaclyn Raeburn, Louise S. Birchall, Jan Sadownik, Fiona C. Coomer, I-Hsin Lin, Edmund J. Cussen, Neil T. Hunt, Tell Tuttle, Simon J. Webb, Dave J. Adams and Rein V. Ulijn. Sequence/structure relationships in aromatic dipeptide hydrogels formed under thermodynamic control by enzyme-assisted self-assembly. 2012 January; 8: 5595-5602. eScholarID:175638 | DOI:10.1039/c2sm25224d Noble, GT; Mart, RJ; Liem, KP; Webb, SJ. Supramolecular Chemistry of Membranes. In: Philip A. Gale and Jonathan W. Steed, ed. Supramolecular Chemistry: From Molecules to Nanomaterials. 4. Chichester, John Wiley & Sons.2012: eScholarID:175632 de Cogan, F; Gough, JE; Webb, SJ. Adhesive interactions between cells and biotinylated phospholipid vesicles in alginate: towards new responsive biomaterials. J. Mater. Sci.-Mater. M. 2011; 22: 1045-1051. eScholarID:138771 | DOI:10.1007/s10856-011-4271-1 Felicity de Cogan, Andrew Booth, Dr. Julie E. Gough and Dr. Simon J. Webb. Conversion of Magnetic Impulses into Cellular Responses by Self-Assembled Nanoparticle–Vesicle Hydrogels. Angewandte Chemie International Edition. 2011 December; 50(51): 12290-12293. eScholarID:141143 | DOI:10.1002/anie.201103469 Wilson, CP; Boglio, C; Ma, L; Cockroft, SL; Webb, SJ. Palladium(II)-mediated assembly of biotinylated ion channels. Chem. Eur. J. 2011; 17: 3465-3473. eScholarID:138770 | DOI:10.1002/chem.201002031 Devi, U; Brown, JRD; Almond, A; Webb, SJ. Pd(II)-mediated assembly of porphyrin channels in bilayer membranes. Langmuir. 2011 January; 27: 1448-1456. eScholarID:138769 | DOI:10.1021/la104152s