Morris, Gareth - The University of Manchester

个人简介

I was successively an undergraduate, postgraduate and research fellow at Magdalen College Oxford from 1972 to 1981, first as a Demy and subsequently as a graduate student (supervised by Ray Freeman) and as a Fellow by Examination. In 1978-9 I spent a year's leave of absence with Laurie Hall at the University of British Columbia as an Izaak Walton Killam postdoctoral fellow. In 1982 I moved to Manchester, where I am now Professor of Physical Chemistry. I was awarded the RSC Corday-Morgan prize and medal in 1988, a Leverhulme Fellowship in 1996, and the RSC Industrially-Sponsored Award in Magnetic Resonance Spectroscopy in 2001, and was an invited professor at the Université Pierre et Marie Curie, Paris, in 2010. In 2011 I was awarded the Russell Varian Prize for NMR, and in 2014 I was elected a Fellow of the Royal Society.

研究领域

Our research involves the development of novel NMR spectroscopy techniques, and their application to problems in chemistry, biochemistry, and medicine. NMR is uniquely flexible, allowing great scope for ingenuity in designing experiments. Multidimensional NMR methods allow detailed structure determination for molecules as large as proteins, while recent advances in instrumentation allow the measurement of localised spectra in human beings. Manchester has one of the best-equipped NMR groups in the world, with over ten superconducting spectrometers in Chemistry alone. Current and projected work includes the development and application of diffusion-ordered spectroscopy (DOSY) methods for the analysis of complex mixtures, the development of new methods for imaging pH in the brain, the use of deconvolution techniques to circumvent instrumental limitations, improved techniques for studying chemical kinetics by NMR, the development of improved methods for chemical structure determination, the use of computer-aided methods for the analysis of complex spectra, and improvements to NMR instrumentation.

近期论文

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Guilherme Dal Poggetto, Denize C. Favaro, Mathias Nilsson, Gareth A. Morris,Cláudio F. Tormena. 19F DOSY NMR analysis for spin systems with nJFF couplings. Journal of Magnetic Resonance. 2014 January; eScholarID:225610 | DOI:10.1002/mrc.4047 Istvan Timari, Lukas Kaltschnee, Andreas Kolmer, Ralph W. Adams, Mathias Nilsson, Christina M. Thiele, Gareth A. Morris, Katalin E. Kover. Accurate determination of one-bond heteronuclear coupling constants with "pure shift"€ broadband proton-decoupled CLIP/CLAP-HSQC experiments. Journal of Magnetic Resonance. 2014 February; 2239(130): 130-138. eScholarID:222207 | DOI:10.1016/j.jmr.2013.10.023 Ralph W. Adams, Liam Byrne, Péter Király, Mohammadali Foroozandeh, Liladhar Paudel, Mathias Nilsson, Jonathan Clayden and Gareth A. Morris. Diastereomeric Ratio Determination by High Sensitivity Band-Selective Pure Shift NMR Spectroscopy. Chemical Communications. 2014 January; 50: 2512-2514. eScholarID:217595 | DOI:10.1039/c3cc49659g Johannes Björnerås, Adolfo Botana, Gareth Morris and Mathias Nilsson. Resolving complex mixtures: trilinear diffusion data. Journal of Biomolecular N M R. 2014; 58: 251-257. eScholarID:241997 | DOI:10.1007/s10858-013-9752-8 Juan A. Aguilar, Ralph W. Adams, Mathias Nilsson, Gareth A. Morris. Suppressing exchange effects in diffusion-ordered NMR spectroscopy. Journal of Magnetic Resonance. 2014 January; 238: 16-19. eScholarID:222206 | DOI:10.1016/j.jmr.2013.10.018 Mohammadali Foroozandeh, Ralph W. Adams, Nicola Meharry, Damien Jeannerat, Mathias Nilsson and Gareth A. Morris. Ultrahigh-Resolution NMR Spectroscopy. Angewandte Chemie (International Edition). 2014 May; 53: eScholarID:224527 | DOI:10.1002/anie.201404111 Mohammadali Foroozandeh, Ralph W. Adams, Mathias Nilsson and Gareth A. Morris. Ultrahigh-resolution Total Correlation NMR Spectroscopy. American Chemical Society. Journal. 2014; 136: 11867-11869. eScholarID:241991 | DOI:10.1021/ja507201t Juan A. Aguilar, Gareth A. Morris, Alan M. Kenwright. ’Pure shift’" 1H NMR, a robust method for revealing heteronuclear couplings in complex spectra. R S C Advances. 2014 January; 4: 8278-8282. eScholarID:225613 | DOI:10.1039/C3RA46745G Byrne L, Sola J, Boddaert T, Marcelli T, Adams R, Morris G, Clayden J. Foldamer-Mediated Remote Stereocontrol: > 1,60 Asymmetric Induction. Angewandte Chemie-International Edition. 2014; 53(1): 151-155. eScholarID:242017 | DOI:Doi 10.1002/Anie.201308264 Ebrahimi P, Nilsson M, Morris G, Jensen H, Engelsen S. Cleaning up NMR spectra with reference deconvolution for improving multivariate analysis of complex mixture spectra. Journal of Chemometrics. 2014; 28(8): 656-662. eScholarID:242018 | DOI:Doi 10.1002/Cem.2607 Vieira M, Gramosa N, Ricardo N, Morris G, Adams R, Nilsson M. Natural product mixture analysis by matrix-assisted DOSY using Brij surfactants in mixed solvents. Rsc Advances. 2014; 4(79): 42029-42034. eScholarID:242016 | DOI:Doi 10.1039/C4ra04433a