Miller, Gavin - The University of Manchester

个人简介

Gavin Miller was born in Newport, Wales and read Chemistry at UMIST where he was awarded an MChem. Continuing his studies at the University of Manchester, Gavin undertook a PhD in carbohydrate chemistry, investigating multivalency. He then undertook post-doctoral research positions at Brown University, Providence, USA and at St Andrews University, UK. Gavin then moved to industry, firstly at Ferring, on the design of new treatments for primary dysmenorrhea and secondly at Peakdale Molecular on the design of an anti-nicotine vaccine. Gavin returned to academia and the University of Manchester in 2009, firstly as a PDRA in the MIB on the chemical synthesis of heparan sulfate oligosaccharides and secondly as a fixed-term lecturer in 2013, within the School of Chemistry.

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S. U. Hansen, C. E. Dalton, M. Baráth, G. Kwan, J. Raftery, G. C. Jayson, G. J. Miller, J. M. Gardiner. Synthesis of L-iduronic acid derivatives via [3.2.1] and [2.2.2] L-iduronic lactones from bulk glucose-derived cyanohydrin hydrolysis: A reversible conformationally-switched super-disarmed/re-armed lactone route to heparin disaccharides. The Journal of Organic Chemistry. 2015; eScholarID:259861 | DOI:10.1021/jo502776f Gavin J. Miller, Steen U. Hansen, Marek Baráth, Christian Johannessen, Ewan W. Blanch, Gordon C. Jayson, John M. Gardiner. Synthesis of a heparin-related GlcN–IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy. Carbohydrate Research. 2014; eScholarID:229767 | DOI:10.1016/j.carres.2014.06.026 Gordon C. Jayson*, Gavin J. Miller, Steen U. Hansen, Marek Barath, John M. Gardiner and Egle Avizienyte. The development of anti-angiogenic heparan sulfate oligosaccharides. Biochemical Society. Transactions. 2014; 42: 1596-1600. eScholarID:241870 | DOI:10.1042/BST20140229 Gavin J. Miller, Steen U. Hansen, Egle Avizienyte, Graham Rushton, Claire Cole, Gordon C. Jayson and John M. Gardiner. Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions. Chem. Sci. 2013 May; 4: 3218-3222. eScholarID:207343 | DOI:10.1039/C3SC51217G Steen U. Hansen, Gavin J. Miller, Gordon C. Jayson, and John M. Gardiner. First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide. Org. Lett. 2013; 15: 88-91. eScholarID:207592 | DOI:10.1021/ol303112y Process for the preparation of polysaccharides 2013 March 25. eScholarID:208149 | DOI:http://www.ipo.gov.uk/p-ipsum/Case/ApplicationNumber/GB1304823.6 David C. Pryde, Lyn H. Jones, David P. Gervais, David R. Stead, David C. Blakemore, Matthew D. Selby, Alan D. Brown, Jotham W. Coe, Matthew Badland, David M. Beal, Rebecca Glen, Yvonne Wharton, Gavin J. Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R. Merson, Heather L. Davis, Michael J. McCluskie. Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice. PLOS ONE. 2013 October; 8: . eScholarID:209828 | DOI:10.1371/journal.pone.0076557 Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, and Motonari Uesugi. Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion. J. Am. Chem. Soc. 2013 July; 135: 11032-11039. eScholarID:207589 | DOI:10.1021/ja4018682 Steen U. Hansen1,* Gavin J. Miller1,* Claire Cole, Graham Rushton, Egle Avizienyte, Gordon C. Jayson and John M. Gardiner. Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nat. Commun. 2013 July; 4:2016(DOI: 10.1038/ncomms3016): eScholarID:207591 | DOI:10.1038/ncomms3016