Kell, Douglas - The University of Manchester

个人简介

SRC Postdoctoral Research Fellow, University College of Wales, Aberystwyth, 1978 - 1980. Postdoctoral Research Assistant, University College of Wales, Aberystwyth, 1980 - 1981. SERC Advanced Fellow, University College of Wales, Aberystwyth, 1981 - 1983. 'New Blood' lecturer in Microbial Physiology, Department of Botany & Microbiology, University College of Wales, Aberystwyth, 1983 - 1988. Director, Aber Instruments Ltd, 1988 - 2008 Reader in Microbiology, Dept of Biological Sciences, University College of Wales, Aberystwyth, 1988 - 1992. Personal Chair, University of Wales, 1992 - 2002 Director of Research, Institute of Biological Sciences, UW Aberystwyth, 1997-2002. EPSRC/RSC Research Chair in Bioanalytical Sciences, Dept of Chemistry, UMIST. 2002 (since 2004 School of Chemistry, University of Manchester) - present Director of the Manchester Centre for Integrative Systems Biology 2005-2008 Seconded (0.8 FTE) as Chief Executive, BBSRC (2008-2013) Doctor of Science Honoris Causa, Cranfield 2011 Fellow of the Learned Society of Wales 2012 http://learnedsocietywales.ac.uk/node/344 Fellow of the American Association for the Advancement of Science 2012

研究领域

My interests are focused on the development and application of novel analytical methods to the solution of complex biological problems. Such methods are both experimental and computational, with the majority of the group's activities being 'dry'. The approach is typically referred to as Systems Biology. I was originally the Director of the BBSRC/EPSRC funded Manchester Centre for Integrative Systems Biology. From October 2008 to October 2013 I was seconded for 0.8 FTE to be Chief Executive of the Biotechnology and Biological Sciences Research Council. My blog there was at http://blogs.bbsrc.ac.uk/ and the Group's Home Page is at http://dbkgroup.org/.

近期论文

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Kell D B, Swainston N, Pir P, Oliver S G. Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis. Trends in Biotechnology. 2015 March; eScholarID:260483 | DOI:10.1016/j.tibtech.2015.02.001 Kell, D. B. & Oliver, S. G. How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. Frontiers in Pharmacology. 2014 October; eScholarID:240012 | DOI:10.3389/fphar.2014.00231 Currin A, Swainston N, Day PJ, Kell DB. SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution. Protein Engineering Design and Selection (Online). 2014 August; 27(9): 273-280. eScholarID:240028 | DOI:10.1093/protein/gzu029 Douglas B Kell et al. A community-driven global reconstruction of human metabolism. Nature Biotechnology. 2013 May; 31(5): 419-425. eScholarID:202468 | DOI:10.1038/nbt.2488 Wang, Y., Paszek, P., Horton, C. A., Yue H., White M. R. H., Kell D. B., Muldoon M. R. & Broomhead D. S. A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation. Journal of Theoretical Biology. 2012 March; 297: 137-147. eScholarID:176857 | DOI:doi: 10.1016/j.jtbi.2011.12.014 Miwa, M., Thompson, P., McNaught, J., Kell, D.B. & Ananiadou, S. Extracting semantically enriched events from biomedical literature. BMC Bioinformatics. 2012 May; 13(108): eScholarID:177582 | DOI:doi:10.1186/1471-2105-13-108 Davey, H. M., Cross, E. J. M., Davey, C. L., Gkargkas, K., Delneri, D., Hoyle, D. C., Oliver, S. G., Kell, D. B. & Griffith, G. W. Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals the importance of recycling in maintaining cell viability. Environmental Microbiology. 2012 May; 14(5): 1249-1260. eScholarID:177340 | DOI:DOI: 10.1111/j.1462-2920.2012.02705.x Lee, D., Smallbone, K., Dunn, W. B., Murabito, E., Winder, C. L., Kell, D. B., Mendes, P. & Swainston, N. Improving metabolic flux predictions using absolute gene expression data. BMC Systems Biology. 2012 June; 6(73): eScholarID:177581 | DOI:doi:10.1186/1752-0509-6-73 Kell D.B. Large-scale sequestration of carbon via plant roots in natural and agricultural ecosystems: why and how. Philosophical Transactions of the Royal Society Biological Sciences. 2012 June; 367(1595): 1589-1597. eScholarID:177359 | DOI:doi: 10.1098/rstb.2011.0244 Kell, D.B. Publication: reviews turn facts into understanding. Nature. 2012 October; 490(37): eScholarID:179071 | DOI:doi:10.1038/490037e Kell, D.B. Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?. BioEssays. 2012 January; 34(3): 236-244. eScholarID:176829 | DOI:DOI: 10.1002/bies.201100144 Dikicioglu, D., Dunn, W. B., Kell, D. B., Kirdar, B. & Oliver, S. G. Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment. Molecular Biosystems. 2012 April; 8(6): 1760-1774. eScholarID:177532 | DOI:DOI: 10.1039/C2MB05443D Pir, P., Gutteridge, A., Wu, J., Rash, B., Kell, D. B., Zhang, N. & Oliver, S. G. The genetic control of growth rate: a systems biology study in yeast. BMC Systems Biology. 2012 January; 6(4): eScholarID:176782 | DOI:doi:10.1186/1752-0509-6-4