Llewellyn, Nicholas - University of Illinois at Urbana-Champaign

个人简介

Dr. Llewellyn received his BS and MS degrees in Chemistry in 2004 at Emory University. He then studied as a Marshall Scholar and NSF Graduate Research Fellow at the University of Cambridge, where he earned his PhD in 2008. Dr. Llewellyn worked at the University of Illinois at Urbana-Champaign as a Howard Hughes Medical Institute Research Associate before accepting his current position as lecturer of organic chemistry in 2009. Dr. Llewellyn is a member of the American Chemical Society, the Royal Society of Chemistry, and the Zeta Chapter of the Alpha Chi Sigma professional chemistry fraternity.

近期论文

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Nudelman, I.; Chen, L.; Llewellyn, N. M.; Sahraoui, E.-H.; Cherniavsky, M.; Spencer, J. B.; Baasov, T. Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain. Adv. Synth. Cat. 2008, 350, 1682-1688. Llewellyn, N. M.; Spencer, J. B. Chemoenzymatic acylation of aminoglycoside antibiotics. Chem. Commun. 2008, 3786-3788. Llewellyn, N. M.; Spencer, J. B. News & Views: Enzymes line up for assembly. Nature 2007, 448, 755-756. Llewellyn, N. M.; Li, Y.; and Spencer, J. B. Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Chem. Biol. 2007, 14, 379-386. Truman, A. W.; Huang, F.; Llewellyn, N. M.; Spencer, J. B. Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin. Angew. Chem. Int. Ed. 2007, 46, 1462-1464. Huang, F.; Spiteller, D.; Koorbanally, N. A.; Li, Y.; Llewellyn, N. M.; Spencer, J. B. Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. ChemBioChem 2007, 8, 283-288. Llewellyn, N. M; Spencer, J. B. Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics. Nat. Prod. Rep. 2006, 23, 864-874. Li, Y.; Llewellyn, N. M.; Giri, R.; Huang, F.; Spencer, J. B. Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chem. Biol. 2005, 12, 665-675.