个人简介
教育经历
2008/09 – 2013/07,上海硅酸盐研究所,材料学专业,博士学位
2004/09 – 2008/07,北京科技大学,无机非金属材料专业,学士学位
工作经历:
2017/12至今,上海硅酸盐研究所,特种无机涂层研究中心,硕士生导师
2016/07至今,上海硅酸盐研究所,特种无机涂层研究中心,副研究员
2013/07-2016/07,上海硅酸盐研究所,特种无机涂层研究中心,助理研究员
研究领域
病理状态下骨植入体表面生物涂层基础研究:基于骨微量营养元素和生物抗氧化剂在治疗骨质疏松、糖尿病和风湿性关节炎等方面的功能性,对涂层生物学性能进行改性研究。
骨修复与替代材料产品研发:采用等离子喷涂技术和新型合金制备技术研发具有自主知识产权的,兼具优良生物学和力学性能的骨修复与替代材料产品(例如,人工关节、外固定螺钉和脊柱融合器等)
近期论文
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Kai Li, Dandan Hu, Youtao Xie, Liping Huang and Xuebin Zheng*. Sr-doped nanowires modification of Ca-Si based coatings for improved osteogenic activities and reduced inflammatory reactions. Nanotechnology. 2018, 29: 084001.
Kai Li, Qingyi Shen, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. Incorporation of Cerium Oxide into Hydroxyapatite Coating Protects Bone Marrow Stromal Cells Against H2O2-Induced Inhibition of Osteogenic Differentiation. Biological Trace Element Research. 2018, 182: 91-104.
Lin Lv, Youtao Xie, Kai Li*, Tao Hu, Xiang Lu, Yunzhen Cao,* and Xuebin Zheng*. Unveiling the Mechanism of Surface Hydrophilicity-Modulated Macrophage Polarization. Advanced Healthcare Materials. 2018, 7(19): e1800675. (IF: 5.6) (通讯作者)
Xiang Lu, Kai Li*,Youtao Xie, Shengcai Qi, Qingyi Shen, Jiangming Yu, Liping Huang, Xuebin Zheng*. Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects. Journal of Biomedical Materials Research: Part A. 2018. doi: 10.1002/jbm.a.36456.
Jiangming Yu, Kai Li*, et al. Adhesion behavior of Escherichia coli on plasma-sprayed Zn and Ag co-incorporated calcium silicate coatings with varying surface roughness. Journal of Thermal Spray Technology. 2018. doi.org/10.1007/s11666-018-0800-5. (通讯作者)
Ding Ding, Youtao Xie, Kai Li, Liping Huang, Xuebin Zheng. Black plasma-sprayed Ta2O5 coatings with photothermal effect for bone tumor therapy. Ceramics International. 2018, 44(11): 12002-12006.
Ding Ding, Youtao Xie, Kai Li, Liping Huang, Xuebin Zheng. Micro/nano structural tantalum coating for enhanced osteogenic differentiation of human bone marrow stem cells. Materials. 2018, 11(4): 546.
Ding D, Xie Y, Li K, Zheng X. A Comparative Study of Vacuum and Atmospheric Plasma Sprayed Tantalum Coating for Modification of Titanium Implants. Surface Review and Letters. 2018. doi.org/10.1142/S0218625X19500495"
Kai Li, Qingyi Shen, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. Incorporation of cerium oxide into hydroxyapatite coating regulates osteogenic activity of mesenchymal stem cell and macrophage polarization. Journal of biomaterials applications. 2017, 31(7): 1062-1076.
Kai Li, Jiangming Yu, Youtao Xie, Mingyu You, Liping Huang and Xuebin Zheng*. The effects of cerium oxide incorporation in calcium silicate coating on bone mesenchymal stem cell and macrophage response. Biological Trace Element Research. 2017, 177: 148-158.
Mingyu You, Kai Li*, Youtao Xie, Liping Huang and Xuebin Zheng*. The effects of cerium valence states at cerium oxide coatings on the responses of bone mesenchymal stem cells and macrophages. Biological Trace Element Research. 2017, 179: 259-270. (通讯作者)
Dandan Hu, Kai Li*, Youtao Xie, Houhua Pan, Jun Zhao, Liping Huang and Xuebin Zheng*. The combined effects of nano-topography and Sr ion for enhanced osteogenic activity of bone marrow mesenchymal stem cells (BMSCs). Journal of Biomaterials Applications. 2017, 31(8): 1135-1147. (通讯作者)
Jiangming Yu, Lizhang Xu, Kai Li, Ning Xie, Yanhai Xi, Yang Wang, Xuebin Zheng, Xiongsheng Chen, Meiyan Wang, Xiaojian Ye*. Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits. Scientific reports. 2017, 7: 3440. (共同第一作者)
Lin Lv, Kai Li, Youtao Xie, Yunzhen Cao*, Xuebin Zheng*. Enhanced osteogenic activity of anatase TiO2 film: surface hydroxyl groups induce conformational changes in fibronectin. Materials Science and Engineering C, 2017, 78: 96-104. (IF: 5.0)
Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Jun Zhao, Xuebin Zheng*, Tingting Tang*. Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway. RSC Advances. 2017, 7, 8521.
Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Jun Zhao, Xuebin Zheng*, Tingting Tang*. Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis. Biomedical Materials. 2017, 12, 045006.
Houhua Pan, Youtao Xie, Zequan Zhang, Kai Li, Dandan Hu, Xuebin Zheng*, Qiming Fan*, Tingting Tang*. YAP-mediated mechanotransduction regulates osteogenic andadipogenic differentiation of BMSCs on hierarchical structure. Colloids and Surfaces B: Biointerfaces. 2017, 152: 344–353.
Jiangming Yu, Lizhang Xu, Kai Li, Ning Xie, Yanhai Xi, Yang Wang, Xuebin Zheng, Xiongsheng Chen, Meiyan Wang, Xiaojian Ye*. Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits. Scientific Reports. 2017, 7: 3440. (共同第一作者)
Ding, D., Xie, Y., Li, K., Huang, L., Zheng, X. Improved Mechanical Compatibility and Cytocompatibility of Ta/Ti Double-Layered Composite Coating. Journal of Thermal Spray Technology. 2017, 26(6): 1292-1300.
Jiangming Yu, Lizhang Xu, Ning Xie, Kai Li, Yanhai Xi, Xiling Liu, Xuebin Zheng, Xiongsheng Chen, Xiaojian Ye, and Daixu Wei. Optimal Zn-Modified Ca–Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering. Journal of Nanomaterials. 2017. doi.org/10.1155/2017/7374510