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个人简介

1989-1991 中山大学生物化学系,本科生 1991-1993 堪萨斯大学分子生命科学系,生物化学学士 1993-1998 堪萨斯大学分子生命科学系,生物化学、细胞和分子生物学博士 1998-2002 康奈尔大学应用和工程物理系,博士后 2002-2009 马萨诸塞大学医学院分子医药系,研究助理教授 2009-2013 宾夕法尼亚大学医学院环境医学研究所,研究员 2009-2013 宾夕法尼亚大学医学院环境医学研究所,研究员 2009-2013 宾夕法尼亚大学医学院环境医学研究所肺成像和形态学中心,主任 2013-至今 中国科学院生物物理研究所,研究员、课题组长

研究领域

光学仪器研发和产业化,细胞器生物生成的分子机制

近期论文

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1. Liang Y., Li S., Wang X., Zhang Y., Sun Y., Wang Y., Wang X., He B., Dai W., Zhang H., Wang X., Zhang Q., A comparative study of the antitumor efficacy of responsive prodrug-nanosystem consisting of amphiphilic small-molecule targeting peptide-doxorubicin conjugates with different linkers, J Control Release, 2018, Accept. 2. Liang Y., Li S., Wang X., He B., He B., Dai W., Zhang H., Wang X., Wang Y., Zhou D., ZhangQ., A Nanosystem of Amphiphilic Oligopeptide-Drug Conjugate Actualizing Both αvβ3 Targeting and Reduction-Triggered Release for Maytansinoid, Theranostics, 2017, 7(13): 3306-3318. 3. Yang Y., Wang Q., Wang S.R., Wang Y.*, Xiao Q.*, Representation of time interval entrained by periodic stimuli in the visual thalamus of pigeons, Elife, 2017, 6: e27995. 4. Liang Y.*, Dong C., Zhang J., Deng L., Dong A., A reconstituted thermosensitive hydrogel system based on paclitaxel-loaded amphiphilic copolymer nanoparticles and antitumor efficacy, Drug Dev Ind Pharm,2017, 43(6): 972-979. 5. Xu L., Ren Z., Chow F.E., Tsai R., Liu T., Rizzolio F., Boffo S., Xu Y., Huang S., Lippa C.F., Gong Y., Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plast, 2017, 2017: 3270725. 6. Stacho M., Str?ckens F., Xiao Q.*, Güntürkün O., Functional organization of telencephalic visual association fields in pigeons, Behav Brain Res, 2016,303: 93-102. 7. Liang Y., Xiao L., Zhai Y., Xie C., Deng L., Dong A., Preparation and Characterization of Biodegradable Poly(sebacic anhydride) Chain Extended by Glycol as Drug Carrier, J Appl Polym Sci, 2013, 127(5): 3948-3953. 8. Xiao Q.*, Frost B.J., Motion parallax processing in pigeon (Columba livia) pretectal neurons, Eur J neurosci, 2013, 37(7): 1103-1111. 9. Roszell B.R., Tao J.Q., Yu K.J., Gao L., Huang S., Ning Y., Feinstein S.I., Vite C.H., Bates S.R., Pulmonary Abnormalities in Animal Models Due to Niemann-Pick Type C1 (NPC1) or C2 (NPC2) Disease, PLoS One, 2013, 8(7): e67084. 10. Liang Y., Qiao Y., Guo S., Wang L., Zhai Y., Xie C., Hu R., Deng L., Dong A., Investigation on injectable, thermally and physically gelable poly(ethylene glycol)/poly(octadecanedioic anhydride) amphiphilic triblock copolymer nanoparticles, J Biomater Sci Polym Ed, 2012, 23(1-4): 465-482. 11. Rahaman H., Zhou S., Dodia C., Feinstein S.I., Huang S., Speicher D.W., Fisher A.B., Increased phospholipase A(2) activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein, Biochemistry, 2012, 51(27): 5521-5530. 12. Yu M., Huang S., Yu K.J., Clyne A.M., Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture, Int J Mol Sci, 2012, 13(5): 5554-5570. 13. Feng S., Knodler A., Zhang J., Zhang X., Hong Y., Huang S., Peranen J., Guo W., A Rab8 GEF-effector interaction network regulates primary ciliogenesis, J Biol Chem, 2012, 287(19): 15602-15609. 14. Roszell B.R., Tao J.Q., Yu K.J., Huang S., Bates S.R., Characterization of the Niemann-Pick type C pathway in the lamellar body cholesterol content of alveolar type II cells, Am J Physiol Lung Cell Mol Physiol, 2012, 302(9): L919-932. 15. Zhang L., Yu K., Robert K.W., DeBolt K.M., Hong N., Tao J.-Q., Fukuda M., Fisher A.B., Huang, S.*, Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells, Am J Physiol Lung Cell Mol Physiol, 2011, 301(4): L461-477. 16. Liang Y., Deng L., Chen C., Zhang J., Zhou R., Li X., Hu R., Dong A., Preparation and properties of thermoreversible hydrogels based on methoxy poly(ethylene glycol)-grafted chitosan nanoparticles for drug delivery systems, Carbohydr Polym, 2011, 83(4): 1828-1833. 17. Liang Y., Xiao L., Li Y., Zhai Y., Xie C., Deng L., Dong A., Poly(ester anhydride)/mPEG Amphiphilic Block Co-polymer Nanoparticles as Delivery Devices for Paclitaxel, J Biomater Sci Polym Ed, 2011, 22(4-6): 701-715. 18. Thom S.R., Bhopale V.M., Yang M., Bogush M., Huang S., Milovanova T.N., Neutrophil β2 integrin inhibition by enhanced interactions of vasodilator-stimulated phosphoprotein with s-nitrosylated actin, J Biol Chem, 2011, 286(37): 32854-32865. 19. Thom S.R., Yang M., Bhopale V.M., Huang S., Milovanova T.N., Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries, J Appl Physiol, 2011, 110(2): 340-351. 20. Shuvaev V.V., Han J., Yu K.J., Huang S., Hawkins B.J., Madesh M., Nakada M., Muzykantov V.R., PECAM-targeted delivery of SOD inhibits endothelial inflammatory response, FASEB J, 2011, 25(1): 348-357.

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