个人简介
1983-1986，中国科学院动物研究所硕士研究生
1988-1994，美国科罗拉多州立大学博士研究生
2000-2004，美国哥伦比亚大学助理教授，肿瘤发生
2004年至今生物物理所研究员
近期论文
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Chen C, Wang J, Zhao Y, Chen SP, Hu ZS, Chen L*, Hang HY*. Enhancers improve the AID induced hypermutation in episomal vector for antibody affinity maturation in mammalian cell display. Antibodies. 2018(accepted)
Fan YJ, Liu YH, Wang YL, Kong BJ, Zhao Y, Ye C, An LL*, Hang HY*. Interaction of the checkpoint protein Rad9 and the non-homologous end-joining protein Ku70. Progress in Biochemistry and Biophysics. 2018, 45(10):1054-1067.
Hu ZS, Ye C, Mi W, Zhao Y, Quan C, Li WW*, Li HM*, Hang HY*. Light-scattering detection within the difficult size range of protein particle measurement using flow cytometry. Nanoscale. 2018 Nov 7;10(41):19277-19285.
Kong BJ, Cao Y, Wu DN, An LL, Ran FL, Lin Y, Ye C, Wang HL*, Hang HY*. Affinity maturation of an antibody for the UV-induced DNA lesions 6,4 pyrimidine-pyrimidones. Applied Microbiology and Biotechnology. 2018 Aug;102(15):6409-6424.
Sun S, Yang X, Wang H, Zhao Y, Lin Y, Ye C, Fang X, Hang H*. Antibody affinity maturation through combining display of two-chain paired antibody and precision flow cytometric sorting. Appl Microbiol Biotechnol. 2016 Jul;100(13):5977-88.
Chen C, Li N, Zhao Y*, Hang H*. Coupling Recombinase-mediated cassette exchange with somatic hypermutation for antibody affinity maturation in CHO cells. Biotechnology & Bioengineering. 2016 Jan;113(1):39-51.
Zhao Y, Ma X, Wang J, Chen S, Yuan H, Xu A, Hang H*, Wu L. The Roles of p21(Waf1/CIP1) and Hus1 in Generation and Transmission of Damage Signals Stimulated by Low-Dose Alpha-Particle Irradiation. Radiat Res. 2015 Dec;184(6):578-85.
Li N, An L, Hang H*. Increased Sensitivity of DNA Damage Response-Deficient Cells to Stimulated Microgravity-Induced DNA Lesions. PLOS ONE. 2015, 10(4):e0125236.
Zhang Z, Cai Z, Li K, Fang Y, An L, Hu Z*, Wang S*, Hang H*. The Effect of lonizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues. Radiation Research. 2015,183:94-104.
Yue H, Zhao Y, Hang H*. Improvement of engineered microbial production of alkanes through a dual-reporter screening system. 生物物理学报. 2014,30(6):424-432.
Yang X, Sun S, Wang HF, Hang H*. Comparison of autotransporter and ice nucleation protein as carrier proteins for antibody display on the cell surface of Escherichia coli. Prog Biochem Biophys. 2013,40(12):1209-1219.
Li T, Wang Z, Zhao Y, He W, An L, Liu S, Liu Y, Wang H, Hang H*. Checkpoint protein Rad9 plays an important role in nucleotide excision repair. DNA Repair. 2013 Apr 1;12(4):284-92.
Chen S , Qiu J, Chen C, Liu C, Liu Y, An L, Jia J, Tang J, Wu L, Hang H*. Affinity maturation of anti-TNF-α scFv with somatic hypermutation in non-B cells. Protein and Cell. 2012 Jun;3(6):460-9.
Zhao Y, He W, Liu WF, Liu CC, Feng LK, Sun L, Yan YB, Hang HY*. Two distinct states of Escherichia coli cells that overexpress the recombinant heterogeneous β-galactosidase. J Biol Chem. 2012 Mar 16;287(12):9259-68.
Wang Y, An L, Jiang Y, Hang H*. Effects of Simulated Microgravity on Embryonic Stem Cells. PLoS One. 2011;6(12):e29214.
Zhang C, Liu Y, Hu Z, An L, He Y, Hang H*. Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses. Protein Cell. 2011 May;2(5):410-22.
He W, Ma X, Yang X, Zhao Y, Qiu J, Hang H*. A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage. Nucleic Acids Res. 2011 Jun;39(11):4719-27.
An L, Wang Y, Liu Y, Yang X, Liu C, Hu Z, He W, Song W and Hang H*. Rad9 is required for B cell proliferation and immunoglobulin class switch recombination. J Biol Chem. 2010 Nov 12;285(46):35267-73.
Qiu J, Jung ST, Georgiou G, Hang HY*. Enrichment of Escherichia coli Spheroplasts Displaying scFv Antibodies specific for antigens expressed on the human cell surface. Appl Microbiol Biotechnol. 2010 Dec;88(6):1385-91.
Cui P, Lin Q, Xin C, Han L, An L, Wang Y, Hu Z, Ding F, Zhang L, Hu S*, Hang H*, Yu J*. Hydroxyurea-induced Global Transcriptional Suppression in Mouse ES Cells. Carcinogenesis. 2010 31(9):1661-8.
Han L, Hu Z, Liu Y, Wang X, Hopkins KM, Lieberman HB, Hang H*. Mouse Rad1 deletion enhances susceptibility for skin tumor development. Mol Cancer. 2010 Mar 24;9:67
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