娄继忠 - 中国科学院生物物理研究所 -

个人简介

1990–1994: 吉林大学，学士 1994–1997: 北京大学，硕士 1997–2000: 中国科学院理论物理研究所，博士 2000–2001: 内华达大学拉斯韦加斯分校，博士后 2001–2005: 佐治亚理工学院，博士后 2005–2009: 佐治亚理工学院，研究科学家 2009 - : 中国科学院生物物理研究所研究员，博士生导师

研究领域

肿瘤免疫识别与调控，T细胞功能化改造，力学免疫学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Peng Wu#, Tongtong Zhang#, Baoyu Liu#, Panyu Fei#, Lei Cui#, Rui Qin, Huaying Zhu, Danmei Yao, Ryan J. Martinez, Wei Hu, Chenyi An, Yong Zhang, Junwei Liu, Jiawei Shi, Juan Fan, Weiwei Yin, Jie Sun, Chun Zhou, Xun Zeng, Chenqi Xu, Jianan Wang, Brian D. Evavold, Cheng Zhu, Wei Chen* and Jizhong Lou*, Mechano-regulation of peptide-MHC class I conformations determines TCR antigen recognition, Mol Cell, 2019 Mar 7;73(5):1015-1027.e7. 2. Song G, Chen H, Sheng G, Wang Y*, Lou J.*, Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome, Biochemistry. 2018 Apr 17;57(15):2179-2183. 3. Zeng Y#, Cui Y#, Zhang Y, Zhang Y, Liang M, Chen H, Lan J, Song G*, and Lou J*, The Initiation, Propagation and Dynamics of CRISPR-SpyCas9 R-loop Complex, Nucleic Acids Research, 2018 Jan 9;46(1):350-361. 4. Shi Y, Zhang Y, Lou J., The influence of cell membrane and SNAP25 linker loop on the dynamics and unzipping of SNARE complex, PLoS One. 2017 Apr 20;12(4):e0176235. doi: 10.1371/journal.pone.0176235. 5. Gao K., Zhang Y., and Lou J., Exploring the Membrane Fusion Mechanism through Force-Induced Disassembly of HIV-1 Six-Helix Bundle, Biochem Biophys Res Commun. 473(4):1185-90, 2016. 6. Yang S, Wang X, Cui L, Ding X, Niu L, Yang F, Wang C, Wang CC, Lou J. Compact conformations of human protein disulfide isomerase. PLoS One. 2014 Aug 1;9(8):e103472. 7. Lee CY, Lou J, Wen KK, McKane M, Eskin SG, Ono S, Chien S, Rubenstein PA, Zhu C, McIntire LV., Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds, Proc Natl Acad Sci U S A. 110(13):5022-7, 2013. 8. Zhang Y., and Lou J., The Ca2+ Influence on Calmodulin Unfolding Pathway: A Steered Molecular Dynamics Simulation Study. PLoS ONE 7(11):e49013, 2012. 9. Xiang X., Lee C.-Y., Li T., Chen W., Lou J., and Zhu, C., Structural basis and kinetics of force-induced conformational changes of an A domain-containing integrin. PLoS ONE 6(11): e27946, 2011. 10. Yago T., Lou J., Wu T., Yang J., Miner J. J., Coburn L., Lopez J. A., Cruz M. A., Dong J.-F., McIntire L. V., McEver R. P., and Zhu C., Platelet glycoprotein Ibα forms catch bonds with WT VWF but not with type 2B von Willebrand Disease VWF, J. Clin. Invest., 118:3195-3207 (2008). 11. Lou J., and Zhu C., Flow induces loop to β-hairpin transition on the β-switch of platelet glycoprotein Ibα, Proc. Natl. Acad. Sci. USA, 105:13847-13852 (2008). 12. Lou J., Yago T., Klopocki A. G., Metha P., Chen W., Zarnitsyna V. I., Bovin N. V., Zhu C., and McEver R. P., Flow-enhanced adhesion regulated by a selectin interdomain hinge, J. Cell Biol., 174:1107-1117 (2006). 　　