个人简介
简历&研究组工作摘要
2000-2003在中国科学院武汉病毒所和沈阳应用生态所联合培养攻读博士学位，主要从事结核分枝杆菌耐药检测生物芯片研究。
2003年在日本KINKI大学进行博士后研究，主要从事蛋白质组学研究工作。
2004-至今在中国科学院生物物理研究所主要从事结核病系统生物学研究。
2011年在爱因斯坦医学院微生物学和免疫学系结核病研究领域著名教授John Chan实验室开展结核分枝杆菌感染及宿主免疫反应相关研究。
主要学术任职情况
2017.5-2020.5 中华医学会结核病分会结核病基础研究专业委员会主任委员
2016.7-至今 中国防痨协会结核病转化医学分会主任委员
2016.7-至今 Journal of Biological Chemistry编委
2015.12-至今 中国防痨协会结核病基础专业分会常委
2011.10-2016.10 中国微生物学会分析微生物专业委员委员
2011.4-2015.4 中国防痨协会基础细菌免疫学专业委员会副主任委员副主任委员
2009.7-2013.6 中国生物物理学会副秘书长
近期论文
查看导师新发文章
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1. Gu S, Li W, Zhang H, Fleming J, Yang W, Wang S, Wei W, Zhou J, Zhu G, Deng J, Hou J, Zhou Y, Lin S, Zhang XE, Bi L*. The β2 clamp in the Mycobacterium tuberculosis DNA polymerase III αβ2ε replicase promotes polymerization and reduces exonuclease activity. Sci Rep. 2016 Jan 29;6:18418. PubMed PMID: 26822057; PubMed Central PMCID: PMC4731781.
2. Zheng P, Xiong Q, Wu Y, Chen Y, Chen Z, Fleming J, Gao D, Bi L*, Ge F.Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells. Mol Cell Proteomics, 2015, 14:1447-63.
3. Zhang XL, Li DF, Fleming J, Wang LW, Zhou Y, Wang DC, Zhang XE, Bi LJ*. Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase. FASEB J. 2015 Dec;29(12):4804-14. PubMed PMID: 26396239.
4. Deng J, Bi L, Zhou L, Guo SJ, Fleming J, Jiang HW, Zhou Y, Gu J, Zhong Q, Wang ZX, Liu Z, Deng RP, Gao J, Chen T, Li W, Wang JF, Wang X, Li H, Ge F, Zhu G, Zhang HN, Gu J, Wu FL, Zhang Z, Wang D, Hang H, Li Y, Cheng L, He X, Tao SC, Zhang XE. Mycobacterium tuberculosis proteome microarray for global studies of protein function and immunogenicity. Cell Rep, 2014, 9:2317-29.
5. Zhang H, Li D, Zhao L, Fleming J, Lin N, Wang T, Liu Z, Li C, Galwey N, Deng J, Zhou Y, Zhu Y, Gao Y, Wang T, Wang S, Huang Y, Wang M, Zhong Q, Zhou L, Chen T, Zhou J, Yang R, Zhu G, Hang H, Zhang J, Li F, Wan K, Wang J, Zhang XE & Bi L*. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. Nature Genetics, 2013, 45: 1255-60.
6. Li W, Li D, Hu Y, Zhang XE, Bi L*, Wang D. Crystal structure of L, D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis. Cell Res. 2013, 23: 728-31.
7. Wang T, Sun H, Cheng F, Zhang XE, Bi L*, Jiang T. Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease. Nucleic Acids Research, 2013, 41: 7556-65.
8. Tao J, Han J, Wu H, Hu X, Deng J, Fleming J, Maxwell A, Bi L*, Mi K. Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance. Nucleic Acids Res. 2013 41: 2370-81.
9. Wu J, Zhang Z, Mitchenall LA, Maxwell A, Deng J, Zhang H, Zhou Y, Chen YY, Wang DC, Zhang XE, Bi L*. The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage. Nucleic Acid Res. 2011, 39: 8488-502.
10. Fu G, Wu J, Liu W, Zhu D, Hu Y, Deng J, Zhang XE, Bi L*, Wang DC.Crystal structure of DNA gyrase B' domain from Mycobacterium tuberculosis sheds lights on the mechanism for T-segment navigation. Nucleic Acids Res. 2009, 37: 5908-5916.
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