个人简介
1994- 1998 北京大学，生理及生物物理学士
1998- 2003 中科大研究生院/中科院生物物理所，生物物理博士
2004- 2007 美国加州大学旧金山分校，博士后
2007- 2009 美国芝加哥西北大学，研究助理教授
2009- 中科院生物物理研究所研究员，博士生导师
研究领域
本研究组以果蝇为动物模型，探索高级脑功能的细胞分子机制，涉及的研究领域和方法包括神经发育生物学、分子遗传学、学习认知行为的神经环路等方面。我们将以已有的行为范式（进食，睡眠和学习记忆）为基础，深入研究单基因对细胞形态、神经网络发育、及高级脑功能的作用，并探讨环境因素，如地磁场等对生物高级脑功能的影响及其机制
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1.Jinghan Sun*, Chang Liu*, Xiaobing Bai*, Li Xiaoting, Zhiping Zhang, Yunpeng Zhang, Jing Guo, Yan Li#.（2017）Drosophila FIT is a protein-specific satiety hormone essential for feeding control, Nature Communication.8:14161.
2.Yunpeng Zhang, Jing Guo, Aike Guo#, Yan Li#.(2016) Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner.Neuroscience.22;332:149-59.
3.Qingqing Liu, Xing Yang, Jingsong Tian, Zhongbao Gao, Meng Wang, Yan Li#, and Aike Guo#.(2016) Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila.Elife.2016, 24;5.
4.Xiaoting Li, Yan Wang, Huan Wang, Tongtong Liu, Jing Guo, Wei Yi, and Yan Li#.(2016) Epithelia-derived wingless regulates dendrite directional growth of Drosophila ddaE neuron through the Fz-Fmi-Dsh-Rac1 pathway.Molecular Brain.9:46.
5.Yan Wang#, Huan Wang, Xiaoting Li, and Yan Li#.(2016) Epithelial microRNA-9a regulates dendrite growth through Fmi-Gq signaling in Drosophila sensory neurons.Dev Neurobiol.76(2):225-37.
6.Chang Liu, Xiaobing Bai, Jinghan Sun, Xiaofan Zhang, and Yan Li#.(2015) Behavioral Switch of Food Preference upon Sugar Deficiency Is Regulated by GPCRs in Drosophila.J Genet Genomics.20;42(7):409-12.
7.Nannan Chen, Aike Guo#, and Yan Li#.(2015) Aging accelerates memory extinction and impairs memory restoration in Drosophila.Biochem Biophys Res Commun.460(4):944-8.
8.Wei Yi, Yunpeng Zhang, Yinjun Tian, Jing Guo, Yan Li#, and Aike Guo#.(2013) A Subset of Cholinergic Mushroom Body Neurons Requires Go Signaling to Regulate Sleep in Drosophila.Sleep.36(12):1809-21.
9.Zhiping Zhang, Xiaoting Li, Jing Guo, Yan Li#, and Aike Guo#.(2013) Two Clusters of GABAergic Ellipsoid Body Neurons Modulate Olfactory Labile Memory in Drosophila.J Neurosci.33(12):5175–81.
10.Jing Ren, Jinghan Sun, Yunpeng Zhang, Tong Liu, Qingzhong Ren, Yan Li#, and Aike Guo#.(2012) Down-regulation of Decapping Protein 2 Mediates Chronic Nicotine Exposure Induced Locomotor Hyperactivity in Drosophila.PLoS ONE.7(12):e52521.
11.Xiaowen Liu, Bo Ma, Asrar B Malik, Haiyang Tang, Tao Yang, Bo Sun, Gang Wang, Richard D Minshall, Yan Li, Yong Zhao, Richard D Ye, and Jingsong Xu.(2012) Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.Nature Immunology.13(5): 457-64.
12.Yan Li#, Payal Ray, Elizabeth J.Rao, Chen Shi, Weirui Guo, Xiaoping Chen, Elvin A.Woodruff, and Jane Wu?.(2010) A Drosophila model for TDP-43 proteinopathy.Proc.Natl.Acad.Sci.U.S.A.16;107(7):3169-74.
13.Yubing Lu*, Fay Wang*, Yan Li*, Jacob Ferris, Jin-A Lee, and Fen-Biao Gao.(2009) The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches.Hum.Mol.Genet.1;18(3):454-62.
14.Xia-Lian Xu*, Yan Li*, Fay Wang, and Fen-Biao Gao.(2008) The steady state level of the nervous system specific microRNA-124a is regulated by dFMR1 in Drosophila.J Neurosci.28(46):11883-9.
15.Yan Li*, Fay Wang*, Jina Lee, and Fenbiao Gao.(2006) MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila.Gen.& Dev.20.2793-2805.
16.Yan Li, Tong Liu, Yueqing Peng, Chunyan Yuan, and Aike Guo.(2004) Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and nonneural tissues.J Neurobiol.61(3):343-58.
京公网安备 11010802027423号