Denmark, Scott E. - University of Illinois at Urbana-Champaign

个人简介

Scott E. Denmark was born in Lynbrook, NY in 1953. He obtained a S. B. from the Massachusetts Institute of Technology in 1975 and a D.Sc. Tech. from the ETH-Zürich under the direction of Albert Eschenmoser in 1980. That same year he was appointed as assistant professor at the University of Illinois and since 1991 has been the Reynold C. Fuson Professor of Chemistry. Professor Denmark has won a number of honors including the Pedler and Robert Robinson Medals (RSC), the Aldrich Award for Creative Work in Synthetic Organic Chemistry, Brown Award for Creative Research in Synthetic Methods, the F. S. Kipping Award in Silicon Chemistry (ACS), the Prelog Medal, Noyori Prize and the Paracelsus Prize. He is currently on the Board of Directors of Organic Reactions and Organic Syntheses and serves on the Editorial Advisory Boards of the Journal of the American Chemical Society, the Journal of Organic Chemistry and Organic Letters.

研究领域

synthetic organic chemistry; invention of new organic reactions (organoelement chemistry); elucidation of structure-reactivity-selectivity relationships (mechanistic studies); total synthesis of natural products (alkaloids, polypropionates, polyenes, C-aryl glycosides)

近期论文

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Extrapolative Prediction Of Enantioselectivity Enabled By Computer-driven Workflow, New Molecular Representations And Machine Learning Denmark, S. E., Zahrt, A. F., Henle, J. J., Rose, B. T., Wang, Y. & Darrow, W., May 30 2023, U.S. Patent No. 11664093 Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts Lexa, K. W., Belyk, K. M., Henle, J., Xiang, B., Sheridan, R. P., Denmark, S. E., Ruck, R. T. & Sherer, E. C., Mar 18 2022, In: Organic Process Research and Development. 26, 3, p. 670-682 13 p. Enantioselective Inter- and Intramolecular Sulfenofunctionalization of Unactivated Cyclic and (Z)-Alkenes Matviitsuk, A., Panger, J. L. & Denmark, S. E., 2022, In: ACS Catalysis. 12, p. 7377-7385 9 p. Extraction Of Selected Platinum-group Metals From Supported Catalyst Denmark, S. E. & Ibrahim, M. Y. S., Aug 30 2022, U.S. Patent No. 11427887 High-Level Data Fusion Enables the Chemoinformatically Guided Discovery of Chiral Disulfonimide Catalysts for Atropselective Iodination of 2-Amino-6-arylpyridines Rose, B. T., Timmerman, J. C., Bawel, S. A., Chin, S., Zhang, H. & Denmark, S. E., Dec 21 2022, In: Journal of the American Chemical Society. 144, 50, p. 22950-22964 15 p. Potassium Trimethylsilanolate-Promoted, Anhydrous Suzuki-Miyaura Cross-Coupling Reaction Proceeds via the "boronate Mechanism": Evidence for the Alternative Fork in the Trail Delaney, C. P., Marron, D. P., Shved, A. S., Zare, R. N., Waymouth, R. M. & Denmark, S. E., Mar 16 2022, In: Journal of the American Chemical Society. 144, 10, p. 4345-4364 20 p. A Conformer-Dependent, Quantitative Quadrant Model Zahrt, A. F., Rinehart, N. I. & Denmark, S. E., May 7 2021, In: European Journal of Organic Chemistry. 2021, 17, p. 2343-2354 12 p. A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands Shrestha, B., Rose, B. T., Olen, C. L., Roth, A., Kwong, A. C., Wang, Y. & Denmark, S. E., Feb 19 2021, In: Journal of Organic Chemistry. 86, 4, p. 3490-3534 45 p. Catalytic, Enantioselective Diamination of Alkenes Tao, Z. L. & Denmark, S. E., 2021, (Accepted/In press) In: Synthesis (Germany). ss-2021-r0324-sr. Catalytic, Enantioselective Syn-Oxyamination of Alkenes Mumford, E. M., Hemric, B. N. & Denmark, S. E., Aug 25 2021, In: Journal of the American Chemical Society. 143, 33, p. 13408-13417 10 p. Computational methods for training set selection and error assessment applied to catalyst design: Guidelines for deciding which reactions to run first and which to run next Zahrt, A. F., Rose, B. T., Darrow, W. T., Henle, J. J. & Denmark, S. E., Apr 2021, In: Reaction Chemistry and Engineering. 6, 4, p. 694-708 15 p. Dreams, False Starts, Dead Ends, and Redemption: A Chronicle of the Evolution of a Chemoinformatic Workflow for the Optimization of Enantioselective Catalysts Rinehart, N. I., Zahrt, A. F., Henle, J. J. & Denmark, S. E., May 4 2021, In: Accounts of chemical research. 54, 9, p. 2041-2054 14 p. Heteroaryl-Heteroaryl, Suzuki-Miyaura, Anhydrous Cross-Coupling Reactions Enabled by Trimethyl Borate Kassel, V. M., Hanneman, C. M., Delaney, C. P. & Denmark, S. E., 2021, (Accepted/In press) In: Journal of the American Chemical Society. 143, 34, p. 13845-13853 9 p. Leveraging Machine Learning for Enantioselective Catalysis: From Dream to Reality Rinehart, N. I., Zahrt, A. F. & Denmark, S. E., Aug 2021, In: Chimia. 75, 7-8, p. 592-597 6 p. Stereochemical language in supramolecular polymer chemistry: How we can do better Palmans, A. R. A., Meijer, E. W. & Denmark, S. E., Jun 15 2021, In: Journal of Polymer Science. 59, 12, p. 1171-1174 4 p. Anhydrous, homogeneous, suzuki-miyaura cross-coupling of boronic esters using potassium trimethylsilanolate Delaney, C. P., Heyboer, E. M. & Denmark, S. E., 2020, In: Organic Syntheses. 97, p. 245-261 17 p. Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins Bigler, R., Mack, K. A., Shen, J., Tosatti, P., Han, C., Bachmann, S., Zhang, H., Scalone, M., Pfaltz, A., Denmark, S. E., Hildbrand, S. & Gosselin, F., Feb 10 2020, In: Angewandte Chemie - International Edition. 59, 7, p. 2844-2849 6 p. Catalytic, Enantioselective Sulfenofunctionalization of Alkenes: Development and Recent Advances Matviitsuk, A., Panger, J. L. & Denmark, S. E., Nov 2 2020, In: Angewandte Chemie - International Edition. 59, 45, p. 19796-19819 24 p. Cautionary Guidelines for Machine Learning Studies with Combinatorial Datasets Zahrt, A. F., Henle, J. J. & Denmark, S. E., Nov 9 2020, In: ACS Combinatorial Science. 22, 11, p. 586-591 6 p. Demystifying the asymmetry-amplifying, autocatalytic behaviour of the Soai reaction through structural, mechanistic and computational studies Athavale, S. V., Simon, A., Houk, K. N. & Denmark, S. E., Apr 1 2020, In: Nature Chemistry. 12, 4, p. 412-423 12 p. Development of a Computer-Guided Workflow for Catalyst Optimization. Descriptor Validation, Subset Selection, and Training Set Analysis Henle, J. J., Zahrt, A. F., Rose, B. T., Darrow, W. T., Wang, Y. & Denmark, S. E., Jul 1 2020, In: Journal of the American Chemical Society. 142, 26, p. 11578-11592 15 p. Enantioselective Synthesis of γ-Lactams by Lewis Base Catalyzed Sulfenoamidation of Alkenes Panger, J. L. & Denmark, S. E., Apr 3 2020, In: Organic Letters. 22, 7, p. 2501-2505 5 p. Quantitative Structure-Selectivity Relationships in Enantioselective Catalysis: Past, Present, and Future Zahrt, A. F., Athavale, S. V. & Denmark, S. E., Feb 12 2020, In: Chemical reviews. 120, 3, p. 1620-1689 70 p. Structural contributions to autocatalysis and asymmetric amplification in the soai reaction Athavale, S. V., Simon, A., Houk, K. N. & Denmark, S. E., Oct 28 2020, In: Journal of the American Chemical Society. 142, 43, p. 18387-18406 20 p. (R)-n,n’-dimethyl-1,1’-binaphthyldiamine Denmark, S. E. & Ryabchuk, P. G., 2019, In: Organic Syntheses. 96, p. 382-399 18 p. A Dinuclear Mechanism Implicated in Controlled Carbene Polymerization Zhukhovitskiy, A. V., Kobylianskii, I. J., Thomas, A. A., Evans, A. M., Delaney, C. P., Flanders, N. C., Denmark, S. E., DIchtel, W. R. & Toste, F. D., Apr 24 2019, In: Journal of the American Chemical Society. 141, 16, p. 6473-6478 6 p. a