马跃 - 中国科学院生物物理研究所 -

个人简介

1994-2000年马萨诸塞大学神经与行为学专业，博士 2000-2003年威斯康星大学灵长类研究中心Dr. James Thomson 实验室，博士后 2003-2006年华盛顿大学生物化学系，高级研究人员 2006年至今中国科学院生物物理研究所，研究员

研究领域

1）人源化胚胎干细胞培养系统的建立。2）人胚胎干细胞高效分化为心肌细胞的方法及机理研究。3）高纯度并可用于临床级别的心肌细胞分离方法的建立。4）更安全、高效产生诱导多能干细胞的方法研究

近期论文

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1. Zhang X.Q., Cao H.H., Bai S.Y., Huo W.B., Ma Y. (2017) Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells. Stem Cell Res. 20:21-29 2. Pei F, Jiang J.J., Bai S.Y., Cao H.H., Tian L.Y., Zhao Y, Yang C.X., Dong H.H., Ma Y. (2017) Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells. Stem Cell Res. 19:94-103 3. Zhao J.J., Cao H.H., Tian L.Y., Huo W.B., Zhai K, Wang P, Ji G.J., Ma Y. (2017) Efficient Differentiation of TBX18+/WT1+ Epicardial-Like Cells from Human Pluripotent Stem Cells Using Small Molecular Compounds. Stem Cells Dev. 1;26(7):528-540 4. Jiang J.J., Han P.C., Zhang Q.Z., Zhao J.M., Ma Y. (2012) Cardiac Differentiation of Human pluripotent Stem Cells. J. Cell. Mol. Med. 16(8):1663-8. 5. Mou X.N., Wu Y.B., Cao H.H., Meng Q.Z., Wang Q.H., Sun C.C., Hu S.S., Ma Y., Zhang H.（2012）Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down Syndrome. Stem Cell Research & Therapy 3:14 6. Wang Q.H., Mou X.N., Cao H.H., Meng Q.Z., Ma Y.N., Han P.H., Jiang J.J., Zhang H., Ma Y. (2011) A novel xeno-free and feeder-cell-free system for human pluripotent stem cell culture. Protein & Cell 3(1):51-59 7. Zhang Q., Jiang J., Han P., Yuan Q., Zhang J., Zhang X., Xu Y., Cao H., Meng Q., Chen L., Tian T., Wang X., Li P., Hescheler J., Ji G., Ma Y. (2010) Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Research 21:579-587 8. Yao J.Y., Zhang L., Zhang X., He Z.Y., Ma Y., Hui L.J., Wang X., Hu Y.P. (2010) H3K27 trimethylation is an early epigenetic event of p16INK4a silencing for regaining tumorigenesis in fusion reprogrammed hepatoma cells. J Biol Chem. 285(24):18828-18837. 9. Li F.M., Liu P.Y., Liu C.C., Xiang D, Deng L, Li W.L., Wangensteen K, Song J.G., Ma Y, Hui L.J., Wei L.X., Li L.S., Ding X.Y., Hu Y.P., He Z.Y., Wang X. (2010) Hepatoblast-like progenitor cells derived from embryonic stem cells can repopulate livers of mice. Gastroenterology. 139(6):2158-2169. 10. He J.Q., Ma Y, Lee Y, Thomson J.A., Kamp T.J. (2003) Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res. 11;93(1):32-9. 11. Ma Y, Ramezani A, Lewis R, Hawley RG, Thomson JA. (2003) High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells 21(1):111-7. 12. Ma Y, Certel K, Gao Y, Niemitz E, Mosher J, Mukherjee A, Mutsuddi M, Huseinovic N, Crews S.T., Johnson W.A., Nambu J.R. (2000) Functional interactions between Drosophila bHLH/PAS, Sox, and POU transcription factors regulate CNS midline expression of the slit gene. J Neurosci 20(12):4596-605. 13. Mukherjee A, Shan X, Mutsuddi M, Ma Y, Nambu J.R. (2000) The Drosophila sox gene, fish-hook, is required for postembryonic development. Dev Biol. 217(1):91-106. 14. Ma Y, Niemitz E.L., Nambu P.A., Shan X, Sackerson C, Fujioka M, Goto T, Nambu J.R. (1998) Gene regulatory functions of Drosophila fish-hook, a high mobility group domain Sox protein. Mech Dev. 73(2):169-82.