研究领域

Organic Chemistry

Dr. Williams' research interests lie in the development of methodologies and strategies for the total synthesis of biologically active natural products. The Williams' laboratories have made leading contributions of synthetic chemistry in areas of marine natural products, including macrocycles, antibiotics, and alkaloids. To date, these efforts have described new pathways to approximately 40 complex natural product structures of importance as potential therapeutic agents to advance treatments for cancer, as well as other diseases.

近期论文

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D. R. Williams, L. A. Robinson and S. A. Bawel, Conformational Effects and Stereocontrol in Synthesis Studies of Medium-ring Dolabellane Carbocycles, Tetrahedron Lett. 2014, in press, published online December 15. D. R. Williams and A. A. Shah, Total Synthesis of (+)-Ileabethoxazole. Studies of an Intramolecular Iron-Mediated Pauson–Khand [2+2+1] Carbocyclization, J. Am. Chem. Soc. 2014, 136, 8829–8836. D. R. Williams, P. K. Mondal, S. A. Bawel and P. P. Nag, A Stereocontrolled Synthesis of the Tricyclic ABC Ring System of Daphnicyclidin A, Org. Lett. 2014, 16, 1956–1959. D. R. Williams, B. A. Atwater, S. A. Bawel, P. Ke, O. Gutierrez, and D. J. Tantillo, Stereocontrol in Asymmetric SE' Reactions of γ-Substituted α,β-Unsaturated Aldehydes, Org. Lett. 2014, 16, 468–471. D. R. Williams, B. J. Myers, L. Mi, R. J. Binder, Studies for the Total Synthesis of Amphidinolide P, J. Org. Chem. 2013, 78, 4762–4778. D. R. Williams and J. R. Pinchman, Studies of Neodolastanes. Synthesis of the Tricyclic Core of the Trichoaurantianolides, Can. J. Chem. 2013, 91, 21–37. (D. Clive Tribute Issue). D. R. Williams, A. A. Shah, S. Mazumder, and M.H. Baik, Studies of Iron-Mediated Pauson—Khand Reactions of 1,1-Disubstituted-Allenylsilanes: Mechanistic Implications for a Reactive Three-Membered Iron Metallacycle, Chem. Sci. 2013, 4, 238-247. D. R. Williams, C. D. Claeboe, and N. Zorn, A Bidirectional SE' Strategy for 1,5-syn and 1,5-anti Stereocontrol Toward the Synthesis of Complex Polyols, Org. Lett. 2012, 14, 3866–3869. H. A. Soini, S. U. Linville, D. Wiesler, A. L. Posto, D. R. Williams, M. V. Novotny, Investigation of Scents on Cheeks and Foreheads of Large Felines in Connection to the Facial Marking Behavior, J. Chem. Ecol. 2012, 38, 145–156. D. R. Williams and Ramkrishna De, Enantioenriched Formation of Synthons of 1,5-Hexadiene Bis-Epoxides for Construction of Nonracemic cis- and trans-2,5-Disubstituted Tetrahydrofurans, Heterocycles, 2012, 84, 385–391 (A. Padwa Special Issue). D. R. Williams and M. J. Walsh, Silane, 1,1'-(Chloromethylene)bis[1,1,1]-trimethyl-, in Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L., Ed.; John Wiley & Sons Ltd.: Chichester, West Sussex, UK, 2011, pp. 461–463. D. R. Williams, S. V. Plummer and S. Patnaik, Studies for the Enantiocontrolled Preparation of Substituted Tetrahydropyrans: Applications for the Synthesis of Leucascandrolide A Macrolactone, Tetrahedron, 2011, 67, 5083–5097. D. R. Williams, J. C. Klein, N. S. C. Chow, Studies of Intramolecular Diels–Alder Reactions of Nitroalkenes for the Stereocontrolled Synthesis of trans-Decalin Ring Systems, Tetrahedron Lett. 2011, 52, 2120–2123. D. R. Williams and L. Fu, Efficient Suzuki and Stille Reactions for Regioselective Strategies of Incorporation of the 1,3-Oxazole Heterocycle: Mild Desulfonylation for the Synthesis of C4 and C5 Monosubstituted Oxazoles, Synlett, 2010, 1641–1646. D. R. Williams and A. A. Shah, Regioselective Formation of 1,1-Disubstituted Allenylsilanes via Cross-Coupling Reactions of 3-Tri-n-butylstannyl-1-trimethylsilyl-1-propyne, Chem. Commun. 2010, 46, 4297–4299. D. R. Williams and L. Fu, Methodology for the Synthesis of Substituted 1,3-Oxazoles, Synlett, 2010, 591–594. D. R. Williams, M. W. Fultz, T. E. Christos, and J. S. Carter, A General Preparation of (Z)-1-Fluorostilbene Derivatives for the Design of Conformationally Restricted Peptidomimetics, Tetrahedron Lett. 2010, 51, 121–124. D. R. Williams, M. W. Fultz, T. E. Christos, and J. S. Carter, A General Preparation of (Z)-1-Fluorostilbene Derivatives for the Design of Conformationally Restricted Peptidomimetics, Tetrahedron Lett. 2010, 51, 121–124. D. R. Williams, M. J. Walsh, and N. Miller, Studies of Xenicane Diterpenes. A Stereocontrolled Total Synthesis of 4-Hydroxydictyolactone, J. Am. Chem. Soc. 2009, 131, 9038–9045. D. R. Williams and M. J. Walsh, The Ugi Multicomponent Reaction, Name Reactions for Homologations - Part II, Li, J. J. and Corey, E. J., Eds.; Wiley & Sons: Hoboken, NJ, 2009, 786-805. D. R. Williams and J. C. Klein, The Passerini Reaction, Name Reactions for Homologations - Part II, Li, J. J. and Corey, E. J., Eds.; Wiley & Sons: Hoboken, NJ, 2009, 765-785.