Giedroc, David P. - Indiana University

个人简介

David Giedroc earned a B.S. in Biochemistry from the Pennsylvania State University and Ph.D. in Biochemistry from the Vanderbilt University School of Medicine in 1984. Following a postdoctoral stint as an NIH postdoctoral fellow in the laboratory of the late Joseph Coleman at Yale University, he joined the faculty in the Department of Biochemistry and Biophysics at Texas A&M University in 1988. He was appointed Professor of Chemistry at Indiana University in 2007, and served as Chair of Department from 2010-2015. Prof. Giedroc is a Fellow of the AAAS and of the Royal Society of Chemistry.

研究领域

zinc- and copper-specific metal sensor proteins from bacterial pathogens, translational frameshifting, and RNA structure and function in mammalian coronavirus replication.

近期论文

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SHAPE analysis of the RNA secondary structure of the Mouse Hepatitis Virus 5' untranslated region and N-terminal nsp1 coding sequences. Yang D, Liu P, Wudeck EV, Giedroc DP, Leibowitz JL. Virology. 2015 Jan 15;475:15-27. doi: 10.1016/j.virol.2014.11.001. Epub 2014 Nov 21. PMID: 25462342 Select item 253186632. The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus. Luebke JL, Shen J, Bruce KE, Kehl-Fie TE, Peng H, Skaar EP, Giedroc DP. Mol Microbiol. 2014 Dec;94(6):1343-60. doi: 10.1111/mmi.12835. Epub 2014 Nov 17. PMID: 25318663 Select item 253102753. Copper transport and trafficking at the host-bacterial pathogen interface. Fu Y, Chang FM, Giedroc DP. Acc Chem Res. 2014 Dec 16;47(12):3605-13. doi: 10.1021/ar500300n. Epub 2014 Oct 13. PMID: 25310275 Select item 249864304. Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection. Reeves BD, Joshi N, Campanello GC, Hilmer JK, Chetia L, Vance JA, Reinschmidt JN, Miller CG, Giedroc DP, Dratz EA, Singel DJ, Grieco PA. Org Biomol Chem. 2014 Oct 28;12(40):7942-56. doi: 10.1039/c4ob00995a. Epub 2014 Jul 2. PMID: 24986430 Select item 248310145. Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR). Chang FM, Coyne HJ, Cubillas C, Vinuesa P, Fang X, Ma Z, Ma D, Helmann JD, García-de los Santos A, Wang YX, Dann CE 3rd, Giedroc DP. J Biol Chem. 2014 Jul 4;289(27):19204-17. doi: 10.1074/jbc.M114.556704. Epub 2014 May 15. PMID: 24831014 Select item 244637656. Recent developments in copper and zinc homeostasis in bacterial pathogens. Braymer JJ, Giedroc DP. Curr Opin Chem Biol. 2014 Apr;19:59-66. doi: 10.1016/j.cbpa.2013.12.021. Epub 2014 Jan 22. Review. PMID: 24463765 Select item 243677657. Manganese acquisition and homeostasis at the host-pathogen interface. Lisher JP, Giedroc DP. Front Cell Infect Microbiol. 2013 Dec 5;3:91. doi: 10.3389/fcimb.2013.00091. eCollection 2013. Review. PMID: 24367765 Select item 241181298. Co-ordinate synthesis and protein localization in a bacterial organelle by the action of a penicillin-binding-protein. Hughes HV, Lisher JP, Hardy GG, Kysela DT, Arnold RJ, Giedroc DP, Brun YV. Mol Microbiol. 2013 Dec;90(6):1162-77. doi: 10.1111/mmi.12422. Epub 2013 Oct 30. PMID: 24118129 Select item 240670669. Physical characterization of the manganese-sensing pneumococcal surface antigen repressor from Streptococcus pneumoniae. Lisher JP, Higgins KA, Maroney MJ, Giedroc DP. Biochemistry. 2013 Oct 29;52(43):7689-701. doi: 10.1021/bi401132w. Epub 2013 Oct 14. PMID: 24067066 Select item 2360904210. Solution NMR refinement of a metal ion bound protein using metal ion inclusive restrained molecular dynamics methods. Chakravorty DK, Wang B, Lee CW, Guerra AJ, Giedroc DP, Merz KM Jr. J Biomol NMR. 2013 Jun;56(2):125-37. doi: 10.1007/s10858-013-9729-7. Epub 2013 Apr 23. PMID: 23609042 Select item 2338587611. Selenite and tellurite form mixed seleno- and tellurotrisulfides with CstR from Staphylococcus aureus. Luebke JL, Arnold RJ, Giedroc DP. Metallomics. 2013 Apr;5(4):335-42. doi: 10.1039/c3mt20205d. PMID: 23385876 Select item 2335428712. A new structural paradigm in copper resistance in Streptococcus pneumoniae. Fu Y, Tsui HC, Bruce KE, Sham LT, Higgins KA, Lisher JP, Kazmierczak KM, Maroney MJ, Dann CE 3rd, Winkler ME, Giedroc DP. Nat Chem Biol. 2013 Mar;9(3):177-83. doi: 10.1038/nchembio.1168. Epub 2013 Jan 27. PMID: 23354287 Select item 2335382913. Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family. Campanello GC, Ma Z, Grossoehme NE, Guerra AJ, Ward BP, Dimarchi RD, Ye Y, Dann CE 3rd, Giedroc DP. J Mol Biol. 2013 Apr 12;425(7):1143-57. doi: 10.1016/j.jmb.2013.01.018. Epub 2013 Jan 23. PMID: 23353829 Select item 2330289514. Solution structure of mouse hepatitis virus (MHV) nsp3a and determinants of the interaction with MHV nucleocapsid (N) protein. Keane SC, Giedroc DP. J Virol. 2013 Mar;87(6):3502-15. doi: 10.1128/JVI.03112-12. Epub 2013 Jan 9. PMID: 23302895 Select item 2321497215. Energetics of zinc-mediated interactions in the allosteric pathways of metal sensor proteins. Chakravorty DK, Parker TM, Guerra AJ, Sherrill CD, Giedroc DP, Merz KM Jr. J Am Chem Soc. 2013 Jan 9;135(1):30-3. doi: 10.1021/ja309170g. Epub 2012 Dec 26. PMID: 23214972 Select item 2313885716. Backbone and sterospecific methyl side chain resonance assignments of the homodimeric zinc sensor AdcR (32 kDa) in the apo- and Zn(II)-bound states. Guerra AJ, Giedroc DP. Biomol NMR Assign. 2014 Apr;8(1):11-4. doi: 10.1007/s12104-012-9442-6. Epub 2012 Nov 9. PMID: 23138857 Select item 2313577617. ¹H, ¹³C, ¹⁵N resonance assignments of murine hepatitis virus nonstructural protein 3a. Keane SC, Giedroc DP. Biomol NMR Assign. 2014 Apr;8(1):15-7. doi: 10.1007/s12104-012-9443-5. Epub 2012 Nov 8. PMID: 23135776 Select item 2300194718. Backbone resonance assignments of the homotetrameric (48 kD) copper sensor CsoR from Geobacillus thermodenitrificans in the apo- and Cu(I)-bound states: insights into copper-mediated allostery. Coyne HJ 3rd, Giedroc DP. Biomol NMR Assign. 2013 Oct;7(2):279-83. doi: 10.1007/s12104-012-9428-4. Epub 2012 Sep 22. PMID: 23001947 Select item 2261886619. ¹H, ¹³C, and ¹⁵N resonance assignments of NmtR, a Ni(II)/Co(II) metalloregulatory protein of Mycobacterium tuberculosis. Lee CW, Giedroc DP. Biomol NMR Assign. 2013 Oct;7(2):145-8. doi: 10.1007/s12104-012-9397-7. Epub 2012 May 22. PMID: 22618866 Select item 2257344020. Illuminating allostery in metal sensing transcriptional regulators. Grossoehme NE, Giedroc DP. Methods Mol Biol. 2012;875:165-92. doi: 10.1007/978-1-61779-806-1_8. PMID: 22573440