Here the authors show that the biological fate of rare earth nanoparticles can be genetically controlled by SMPD1 in cells, offering insights for the prevention or treatment of rare earth associated hazard effects, such as inflammation and pneumoconiosis.

The local acidic interfacial environment limits oxygen evolution at high current densities. Here, the authors report that intercalating squaric acid anions into NiFe-based electrocatalysts stabilizes the interface, inhibiting acidification and achieving stability for 700 h at 3.0 A cm⁻².

Nonlinearity can profoundly alter signals. Here, authors introduce an inverse material design method to achieve targeted nonlinear dynamic responses. Applied to impact mitigation and pulse shaping, this approach reveals both strong sensitivity to constituent nonlinearity and the potential for high-performance designs.

A key challenge for high-voltage lithium-ion batteries is electrolyte instability. Here, authors use machine learning-guided experiments to rapidly discover optimal dual electrolyte additives, identifying combinations such as LiDFOB and succinic anhydride that improve multiple performance metrics.

Lignin valorization has long been hindered by the challenge of precisely controlling product selectivity. Here, the authors construct a robust electrocatalytic system that enables pH-driven switching between depolymerization and hydrogenation pathways with high selectivity.

Here the authors show that the biological fate of rare earth nanoparticles can be genetically controlled by SMPD1 in cells, offering insights for the prevention or treatment of rare earth associated hazard effects, such as inflammation and pneumoconiosis.

Transitions to sustainable food systems require shifts in food production and availability, particularly the replacement of animal-based protein with plant-based protein. Here, the authors show that the optimal balance of plant vs animal protein and fat in national food supplies varies with age, suggesting age-specific redistributions to balance health and environmental benefits.

Pacific sub-decadal sea surface temperature (SST) variations have dominantly driven Antarctic atmospheric circulation changes through tropical–polar teleconnections and contributed to recent rapid Antarctic sea ice extent (SIE) decline trends and Southern Ocean subsurface warming.

Large-scale irrigation changes local rainfall patterns, leading to more afternoon rain events 10 to 50 km downwind of irrigated areas. These findings will help constrain climate and weather forecasting models and support regional water management.

This study shows that climate change has caused more frequent land-ocean transboundary migrations of warm-season heatwaves, especially in the tropics, driven by stronger landward winds and increased land-ocean temperature gradient.

The dynamic spatial chromosomal configurations in 3D space demonstrate cell-to-cell variation. Here, authors develop Tensor-FLAMINGO to reconstruct high-resolution single-cell specific 3D genome structures, leading to insights into chromatin folding, gene regulation and disease SNPs.

Double-stranded RNA (dsRNA) is key in immunity and cellular regulation. Here, using the PISA workflow, the authors find 218 proteins with altered solubility upon dsRNA binding. ZNF385A knockout activates interferon-β transcription and increases endogenous dsRNA levels, enhancing the bioactivity of 5-Aza-2’-deoxycytidine and NK cell-mediated cytotoxicity.

Targeting proinflammatory/oxidative enzymes is a promising approach to treat inflammatory diseases. Here the authors present a dual-specificity inhibitor for the simultaneous targeting of Vascular Adhesion Protein-1 and Myeloperoxidase, two cooperative but functionally independent enzymes, and report potent anti-inflammatory effects of the dual inhibitor in multiple animal models of inflammatory disease.

Here the authors show that the biological fate of rare earth nanoparticles can be genetically controlled by SMPD1 in cells, offering insights for the prevention or treatment of rare earth associated hazard effects, such as inflammation and pneumoconiosis.

Here, the authors show that both host and microbially conjugated bile acids (Bas) can provide benefits to IBD patients, but this is dictated by a delicate balance between BA conjugation/deconjugation based on the bacterial bsh genes present.

Transitions to sustainable food systems require shifts in food production and availability, particularly the replacement of animal-based protein with plant-based protein. Here, the authors show that the optimal balance of plant vs animal protein and fat in national food supplies varies with age, suggesting age-specific redistributions to balance health and environmental benefits.

Here, the authors show that both host and microbially conjugated bile acids (Bas) can provide benefits to IBD patients, but this is dictated by a delicate balance between BA conjugation/deconjugation based on the bacterial bsh genes present.

Here, the authors show that high alpha diversity, differences in beta diversity, and a high abundance of Bacteroides in the gut microbiome are associated with positive vaccine take and stool shedding following administration of RV3-BB vaccine in the neonatal schedule, but not in the infant schedule or placebo groups, suggesting that the early-life gut microbiome provides a gut environment that optimizes the potential for a positive vaccine response.

Targeting proinflammatory/oxidative enzymes is a promising approach to treat inflammatory diseases. Here the authors present a dual-specificity inhibitor for the simultaneous targeting of Vascular Adhesion Protein-1 and Myeloperoxidase, two cooperative but functionally independent enzymes, and report potent anti-inflammatory effects of the dual inhibitor in multiple animal models of inflammatory disease.

In the United States, tuberculosis control is focused on prevention of progression from latent tuberculosis infection to TB disease. Here, the authors develop and validate a prediction model to identify individuals at risk of TB disease using data from electronic health records from California.

Transitions to sustainable food systems require shifts in food production and availability, particularly the replacement of animal-based protein with plant-based protein. Here, the authors show that the optimal balance of plant vs animal protein and fat in national food supplies varies with age, suggesting age-specific redistributions to balance health and environmental benefits.

Teaching and leadership are under-studied in connection with the opaque norms that underpin cooperation. The authors show that among egalitarian foragers, influential individuals often pass on these norms, hinting at a possible relationship between leadership and cooperative teaching.

Recent catastrophic weather events across the U.S.—and abroad—have brought the issue of electricity reliability and resilience to the forefront of energy and environmental policy discussions. This manuscript documents an approach to estimate the economic impacts of widespread, long duration (WLD) power interruptions.

Historic documents indicate that fish were introduced to Pyrenean lakes in the 14–15th centuries. Here, the authors examine sedimentary DNA from fish parasites in Lake Redon, suggesting fish were introduced by Late-Roman or Visigoths in the 7th century.

The authors estimate income inequality in the Roman Empire and the Chinese Han Empire. They find that the Han Empire was, overall, more unequal and extractive than the Roman Empire, with the respective one-percenters earning 26% and 19% of total income.