We present a tetrahydrocarbozole-forming carbo-trifluoromethylation of indoles bearing an alkenyl group at the C3 position. The reaction proceeded selectively with the combination of TsOH·H₂O as a catalyst and CH₂Cl₂ as a solvent. The site-selectivity could be altered by changing the reaction solvent; the use of THF instead of CH₂Cl₂ increased the formation of aromatic trifluoromethylation products.

中文翻译：

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控制带有吲哚基侧基的烯烃在三氟甲基化中的位点选择性：含CF ₃的四氢咔唑的合成

我们提出了在C3位置带有烯基的吲哚的四氢咔唑形成碳三氟甲基化。通过将TsOH·H ₂ O作为催化剂和CH ₂ Cl ₂作为溶剂，使反应选择性地进行。可以通过改变反应溶剂来改变位点选择性。使用THF代替CH ₂ Cl _2可以增加芳族三氟甲基化产物的形成。