Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals,Chemistry - A European Journal

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Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2019-01-29 , DOI: 10.1002/chem.201806138
Jia-Bin Han ₁ , Ao Guo ₁ , Xiang-Ying Tang ₁

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A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β‐fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic studies revealed that the electron‐neutral phosphine acts as the deoxygenation reagent.

中文翻译：

通过烷氧基自由基的脱氧进行烯丙基/烯基砜的烷基化

从容易获得的醇衍生物开发了具有挑战性的烷氧基自由基脱氧剂，可在温和的反应条件下轻松合成具有良好官能团耐受性的官能化烯烃。由于烷氧基自由基很容易发生β片段分解或夺氢现象，因此这种使烷氧基自由基脱氧的新策略非常有价值。此外，机理研究表明，电子中性膦可作为脱氧剂。

更新日期：2019-01-29

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