Nitrogen-containing heteroaromatic cores are ubiquitous building blocks in organic chemistry. Herein, we present a family of metal-free intermolecular formal cycloaddition reactions that enable highly selective and orthogonal access to isoquinolines and pyrimidines at will. Applications of the products are complemented by a density functional theory mechanistic analysis that pinpoints the crucial factors responsible for the selectivity observed, including stoichiometry and the nature of the heteroalkyne.

中文翻译：

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不含金属的分子间形式的环加成反应可正交获得氮杂环。

含氮杂芳族核是有机化学中无处不在的构建基块。在这里，我们提出了一个无金属的分子间形式环加成反应的家族，该反应使得能够任意选择地高度选择性和正交地获得异喹啉和嘧啶。密度泛函理论机理分析补充了产品的应用，该机理分析指出了导致观察到的选择性的关键因素，包括化学计量和杂炔的性质。