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Tristearin as a Model Cuticle for High-Throughput Screening of Agricultural Adjuvant Systems
ACS Omega ( IF 3.7 ) Pub Date : 2018-12-05 00:00:00 , DOI: 10.1021/acsomega.8b02656 Graham R. Webster , Nicole B. Bisset , David M. Cahill 1 , Peter Jones 2 , Andrew Killick 2 , Adrian Hawley 3 , Ben J. Boyd
ACS Omega ( IF 3.7 ) Pub Date : 2018-12-05 00:00:00 , DOI: 10.1021/acsomega.8b02656 Graham R. Webster , Nicole B. Bisset , David M. Cahill 1 , Peter Jones 2 , Andrew Killick 2 , Adrian Hawley 3 , Ben J. Boyd
Affiliation
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The widely varied compositions and structures of plant cuticles create problems in the identification of suitable model systems for laboratory testing of adjuvants. We have compared the behavior of an extracted cuticle wax with tristearin, a well characterized crystalline triglyceride, which we propose as a model cuticle for ranking new adjuvant systems for their propensity to disrupt the cuticle barrier. The interaction of adjuvant products and their components with the extracted cuticle wax and tristearin was determined using differential scanning calorimetry and small angle X-ray scattering approaches. The interaction of the additive with tristearin caused a concentration-dependent change in the crystallite level, and correlated between the extracted wax and tristearin. Tristearin was subsequently used to compare the effectiveness of a range of adjuvant products and their major components. This approach has utility to quantify the effects of adjuvant components and enable more judicious selection of adjuvant candidates to progress to plant trials.
中文翻译：
Tristearin作为用于农业佐剂系统高通量筛选的模型表皮
植物表皮的广泛变化的组成和结构在鉴定用于佐剂的实验室测试的合适模型系统时产生了问题。我们将提取的角质层蜡的行为与甘油三硬脂酸酯（一种特性良好的结晶性甘油三酸酯）进行了比较，我们建议将其作为模型角质层，用于对新的佐剂系统进行评级，以评估其破坏角质层屏障的倾向。使用差示扫描量热法和小角度X射线散射方法确定佐剂产品及其成分与提取的表皮蜡和甘油三硬脂精的相互作用。添加剂与甘油三硬脂精的相互作用导致了微晶含量的浓度依赖性变化，并且与提取的蜡和甘油三硬脂精之间存在相关性。随后使用Tristearin比较了一系列佐剂产品及其主要成分的功效。该方法可用于量化佐剂成分的作用，并能够更明智地选择佐剂候选物，以进行植物试验。
更新日期：2018-12-05
中文翻译：
Tristearin作为用于农业佐剂系统高通量筛选的模型表皮
植物表皮的广泛变化的组成和结构在鉴定用于佐剂的实验室测试的合适模型系统时产生了问题。我们将提取的角质层蜡的行为与甘油三硬脂酸酯（一种特性良好的结晶性甘油三酸酯）进行了比较，我们建议将其作为模型角质层，用于对新的佐剂系统进行评级，以评估其破坏角质层屏障的倾向。使用差示扫描量热法和小角度X射线散射方法确定佐剂产品及其成分与提取的表皮蜡和甘油三硬脂精的相互作用。添加剂与甘油三硬脂精的相互作用导致了微晶含量的浓度依赖性变化，并且与提取的蜡和甘油三硬脂精之间存在相关性。随后使用Tristearin比较了一系列佐剂产品及其主要成分的功效。该方法可用于量化佐剂成分的作用，并能够更明智地选择佐剂候选物，以进行植物试验。
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