Microwave‐Assisted Synthesis of N‐Substituted Maleimide Derivatives as Exogenous Antioxidant Agents,Journal of Heterocyclic Chemistry

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Microwave‐Assisted Synthesis of N‐Substituted Maleimide Derivatives as Exogenous Antioxidant Agents
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2018-11-29 , DOI: 10.1002/jhet.3421
Aluru Rammohan _{1,

2} , Guda Mallikarjuna Reddy _{2,

3} , Jarem Raul Garcia ₃ , Grigory V. Zyryanov _{2,

4} , Gundala Sravya ₂ , Nemallapudi Bakthavatchala Reddy ₂ , Gutha Yuvaraja ₅

Affiliation

A series of N‐substituted maleimide derivatives have been developed via acetic acid‐mediated microwave reaction pathway, which was identified as the incomparable method for this maleimide compounds. All the synthesized compounds were tested for antioxidant activity by DPPH and H₂O₂ methods. Compounds 5h and 5m were displayed with higher antioxidant activity in two methods. The structure–activity relationship demonstrated that the compounds having electron releasing substitutions 5h and 5m generally show beneficial activity than electron capture substitution cores. Thus, compounds 5h and 5m may be useful as an exogenous antioxidant.

中文翻译：

微波辅助合成N-取代的马来酰亚胺衍生物作为外源抗氧化剂

通过乙酸介导的微波反应途径开发了一系列N取代的马来酰亚胺衍生物，这被认为是该马来酰亚胺化合物不可比拟的方法。通过DPPH和H ₂ O ₂方法测试所有合成的化合物的抗氧化活性。两种方法均显示化合物5h和5m具有较高的抗氧化活性。结构-活性关系表明，具有电子释放取代基5h和5m的化合物通常显示出比电子捕获取代核更好的活性。因此，化合物5h和5m 可用作外源抗氧化剂。

更新日期：2018-11-29

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