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Ultralight Conductive and Elastic Aerogel for Skeletal Muscle Atrophy Regeneration
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-11-14 , DOI: 10.1002/adfm.201806200 Leyu Wang 1, 2 , Xingying Zhang 2 , Yutong He 1 , Ying Wang 3 , Wen Zhong 4 , Kibret Mequanint 5 , Xiaozhong Qiu 1 , Malcolm Xing 2
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-11-14 , DOI: 10.1002/adfm.201806200 Leyu Wang 1, 2 , Xingying Zhang 2 , Yutong He 1 , Ying Wang 3 , Wen Zhong 4 , Kibret Mequanint 5 , Xiaozhong Qiu 1 , Malcolm Xing 2
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Cell‐free materials that can transmit both mechanical and electrical stimulations provide a promising strategy for myoinjury repair. Skeletal muscle is sensitive to electrical stimulation (ES), and accordingly, materials are required to transmit the electrical signal while maintaining their elasticity to build the cellular communication network in denervated muscle for retarding muscle atrophy. Here, tannic acid functionalized with methacrylate group (TA–MA), dopamine, and hydrothermal reduction are employed in multistep base reduction to fabricate a polydopamine (PDA)/reduced graphite oxide (rGO) aerogel. This mussel‐inspired PDA/rGO aerogel possesses good conductivity, electromechanical stability, and appropriate Young's modulus, which are favorable for the growth and differentiation of C2C12 myoblasts. After the cell‐free PDA/rGO aerogel‐transplanted denervated muscle is loaded with cyclic ES for 3 weeks, the mean muscle fiber size increases by 90% and the maximum contraction force of denervated muscle elevates by 50%, accompanied with a slight inflammation infiltration in muscle. In conclusion, PDA/rGO aerogel is a safe and effective implant for retarding the disuse muscle atrophy.
中文翻译：
超轻导电和弹性气凝胶，用于骨骼肌萎缩再生。
可以传递机械和电刺激的无细胞材料为肌损伤修复提供了一种有前途的策略。骨骼肌对电刺激（ES）敏感，因此，需要材料来传输电信号，同时保持其弹性，以在失神经肌肉中建立细胞通讯网络，从而延缓肌肉萎缩。在这里，用甲基丙烯酸酯基团（TA-MA），多巴胺和水热还原功能化的单宁酸在多步碱还原中用于制造聚多巴胺（PDA）/还原石墨氧化物（rGO）气凝胶。这种贻贝启发的PDA / rGO气凝胶具有良好的导电性，机电稳定性和适当的杨氏模量，有利于C2C12成肌细胞的生长和分化。在无细胞PDA / rGO气凝胶移植的失神经肌肉中加载周期性ES 3周后，平均肌纤维大小增加90％，失神经肌肉的最大收缩力增加50％，并伴有轻微的炎症浸润在肌肉中。总之，PDA / rGO气凝胶是一种安全有效的植入物，可用于延缓废用性肌肉萎缩。
更新日期：2018-11-14
中文翻译：
超轻导电和弹性气凝胶，用于骨骼肌萎缩再生。
可以传递机械和电刺激的无细胞材料为肌损伤修复提供了一种有前途的策略。骨骼肌对电刺激（ES）敏感，因此，需要材料来传输电信号，同时保持其弹性，以在失神经肌肉中建立细胞通讯网络，从而延缓肌肉萎缩。在这里，用甲基丙烯酸酯基团（TA-MA），多巴胺和水热还原功能化的单宁酸在多步碱还原中用于制造聚多巴胺（PDA）/还原石墨氧化物（rGO）气凝胶。这种贻贝启发的PDA / rGO气凝胶具有良好的导电性，机电稳定性和适当的杨氏模量，有利于C2C12成肌细胞的生长和分化。在无细胞PDA / rGO气凝胶移植的失神经肌肉中加载周期性ES 3周后，平均肌纤维大小增加90％，失神经肌肉的最大收缩力增加50％，并伴有轻微的炎症浸润在肌肉中。总之，PDA / rGO气凝胶是一种安全有效的植入物，可用于延缓废用性肌肉萎缩。
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