Synthesis of Polymer Bioconjugates via Photoinduced Atom Transfer Radical Polymerization under Blue Light Irradiation.,ACS Macro Letters

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Synthesis of Polymer Bioconjugates via Photoinduced Atom Transfer Radical Polymerization under Blue Light Irradiation.
ACS Macro Letters ( IF 5.1 ) Pub Date : 2018-09-27 , DOI: 10.1021/acsmacrolett.8b00609
Liye Fu ₁ , Zhenhua Wang ₁ , Sushil Lathwal ₁ , Alan E Enciso ₁ , Antonina Simakova ₂ , Subha R Das ₁ , Alan J Russell ₃ , Krzysztof Matyjaszewski ₁

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A rapid blue-light-induced atom transfer radical polymerization (ATRP) was conducted in a biologically friendly environment. Well-controlled polymerization of oligo(ethylene oxide) methyl ether methacrylate (OEOMA) was successfully performed in aqueous media (1X PBS) under irradiation by blue LED strips. With 10.0 mW/cm2 intensity output at 450 nm, >90% conversion was achieved in 2 h in the presence of a system comprising glucose, glucose oxidase, and sodium pyruvate. Poly-(OEOMA) was synthesized with predetermined M n and low dispersities using low ppm of Cu catalysts. Importantly, secondary structures of proteins, as analyzed by circular dichroism (CD), were preserved under blue-light irradiation due to its lower energy output. The aqueous blue-light ATRP technique was applied to biological systems by synthesizing well-defined protein-polymer and DNA-polymer hybrids by the "grafting-from" method.

中文翻译：

在蓝光照射下通过光诱导的原子转移自由基聚合合成聚合物生物共轭物。

在生物友好的环境中进行了快速的蓝光诱导的原子转移自由基聚合（ATRP）。在蓝色LED灯带的照射下，在水性介质（1X PBS）中成功进行了可控的低聚（环氧乙烷）甲基醚甲基丙烯酸甲酯（OEOMA）的聚合。在包含葡萄糖，葡萄糖氧化酶和丙酮酸钠的系统存在下，在450 nm处以10.0 mW / cm2的强度输出，在2小时内实现了> 90％的转化率。使用低ppm的Cu催化剂以预定的Mn和低分散度合成了Poly-（OEOMA）。重要的是，通过圆二色性（CD）分析的蛋白质二级结构由于其较低的能量输出而在蓝光照射下得以保存。

更新日期：2018-09-27

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