NMR Spectroscopy Unchained: Attaining the Highest Signal Enhancements in Dissolution Dynamic Nuclear Polarization,The Journal of Physical Chemistry Letters

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NMR Spectroscopy Unchained: Attaining the Highest Signal Enhancements in Dissolution Dynamic Nuclear Polarization
The Journal of Physical Chemistry Letters ( IF 4.8 ) Pub Date : 2018-09-04 00:00:00 , DOI: 10.1021/acs.jpclett.8b01687
Peter Niedbalski ₁ , Andhika Kiswandhi ₁ , Christopher Parish ₁ , Qing Wang ₁ , Fatemeh Khashami ₁ , Lloyd Lumata ₁

Affiliation

Dynamic nuclear polarization (DNP) via the dissolution method is one of the most successful methods for alleviating the inherently low Boltzmann-dictated sensitivity in nuclear magnetic resonance (NMR) spectroscopy. This emerging technology has already begun to positively impact chemical and metabolic research by providing the much-needed enhancement of the liquid-state NMR signals of insensitive nuclei such as ¹³C by several thousand-fold. In this Perspective, we present our viewpoints regarding the key elements needed to maximize the NMR signal enhancements in dissolution DNP, from the very core of the DNP process at cryogenic temperatures, DNP instrumental conditions, and chemical tuning in sample preparation to current developments in minimizing hyperpolarization losses during the dissolution transfer process. The optimization steps discussed herein could potentially provide important experimental and theoretical considerations in harnessing the best possible sensitivity gains in NMR spectroscopy as afforded by optimized dissolution DNP technology.

中文翻译：

未链接的NMR光谱：在溶解动态核极化中获得最高的信号增强

通过溶解方法进行的动态核极化（DNP）是缓解核磁共振（NMR）光谱固有的低玻耳兹曼指示灵敏度的最成功方法之一。通过提供急需的不敏感核（如^13）的液态NMR信号增强，这项新兴技术已开始对化学和代谢研究产生积极影响。C降低了数千倍。在此“观点”中，我们提出了关于使溶解DNP中的NMR信号增强最大化所需的关键元素的观点，从低温，DNP仪器条件和样品制备中的化学调整到DNP过程的核心，直至最小化的最新进展。溶出转移过程中的超极化损失。本文讨论的优化步骤可能潜在地提供重要的实验和理论考虑，以利用由优化溶出DNP技术提供的NMR光谱中的最佳可能灵敏度增益。

更新日期：2018-09-04

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