Sulfated polysaccharides from abalone (Haliotis discus hannai Ino) gonad (AGSP) is shown to have various bioactivities, but it remains unknown whether AGSP produces any effect on high fat diet (HFD)-induced obesity. This study indicated that AGSP inhibited weight gain and improved body composition in HFD-fed mice without reducing food consumption. Moreover, AGSP reduced fat accumulation in the liver and epididymal fat tissues of HFD-fed mice via the modulation of lipid metabolism. Such effects could be associated with the improvement of the gut microbiota as indicated by a decreased ratio of Firmicutes/Bacteroidetes and overall structure changes of the gut microbiota. Butyrate as the end product of bacterial fermentation was significantly increased in AGSP-fed mice, and thus may inhibit lipid-related gene expressions via G protein-coupled receptors-dependent pathways. In short, it suggested that AGSP can be used as beneficial polysaccharides to improve obesity and its associated disorders.

鲍鱼（Haliotis discus hannai）中的硫酸多糖。已显示Ino）性腺（AGSP）具有多种生物活性，但尚不清楚AGSP是否对高脂饮食（HFD）引起的肥胖症产生任何影响。这项研究表明，AGSP抑制了喂食HFD的小鼠的体重增加并改善了其身体组成，而没有减少食物的消耗。此外，AGSP通过调节脂类代谢减少了HFD喂养小鼠的肝脏和附睾脂肪组织中的脂肪积累。此类作用可能与肠道菌群的改善有关，如纤毛虫/拟杆菌比率的降低和肠道菌群整体结构的改变所表明的。在由AGSP喂养的小鼠中，作为细菌发酵终产物的丁酸盐显着增加，因此可能通过G蛋白偶联受体依赖性途径抑制脂质相关基因的表达。简而言之，