Fluorinated Boronic Acid-Appended Bipyridinium Salts for Diol Recognition and Discrimination via19F NMR Barcodes,Journal of the American Chemical Society

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Fluorinated Boronic Acid-Appended Bipyridinium Salts for Diol Recognition and Discrimination via19F NMR Barcodes
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2015-12-03 , DOI: 10.1021/jacs.5b10934
Jörg Axthelm ₁ , Helmar Görls ₁ , Ulrich S. Schubert _{2,

3} , Alexander Schiller _{1,

3}

Affiliation

Fluorinated boronic acid-appended benzyl bipyridinium salts, derived from 4,4'-, 3,4'-, and 3,3'-bipyridines, were synthesized and used to detect and differentiate diol-containing analytes at physiological conditions via (19)F NMR spectroscopy. An array of three water-soluble boronic acid receptors in combination with (19)F NMR spectroscopy discriminates nine diol-containing bioanalytes--catechol, dopamine, fructose, glucose, glucose-1-phosphate, glucose-6-phosphate, galactose, lactose, and sucrose--at low mM concentrations. Characteristic (19)F NMR fingerprints are interpreted as two-dimensional barcodes without the need of multivariate analysis techniques.

中文翻译：

氟化硼酸附加双吡啶鎓盐，用于通过 19 F NMR 条码识别和区分二醇

合成了衍生自 4,4'-、3,4'- 和 3,3'-联吡啶的氟化硼酸附加苄基联吡啶鎓盐，并通过 (19) 在生理条件下用于检测和区分含二醇的分析物F 核磁共振光谱。一系列三种水溶性硼酸受体与 (19)F 核磁共振光谱相结合，可区分九种含二醇的生物分析物——儿茶酚、多巴胺、果糖、葡萄糖、1-磷酸葡萄糖、6-磷酸葡萄糖、半乳糖、乳糖和蔗糖——低 mM 浓度。特征 (19)F NMR 指纹被解释为二维条码，无需多变量分析技术。

更新日期：2015-12-03

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