Pyruvate as a cell‐protective agent during cold atmospheric plasma treatment in vitro: Impact on basic research for selective killing of tumor cells,Plasma Processes and Polymers

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Pyruvate as a cell‐protective agent during cold atmospheric plasma treatment in vitro: Impact on basic research for selective killing of tumor cells
Plasma Processes and Polymers ( IF 2.9 ) Pub Date : 2019-09-18 , DOI: 10.1002/ppap.201900088
Claudia Bergemann ₁ , Henrike Rebl ₁ , Anik Otto ₁ , Svenja Matschke ₁ , Barbara Nebe ₁

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Promising investigations on the selective killing of tumor cells were reported using cold atmospheric pressure plasma (CAP) in vitro. Pyruvate, a supplement in cell culture media, could protect cells against the action of reactive oxygen species. Here, we provide an overview of the in vitro studies concerning the selective killing of tumor cells by CAP with special emphasis on pyruvate concentration in the cell culture media. Several former studies were performed in media with different pyruvate content. Our cell experiments confirmed that pyruvate mitigates the action of the plasma‐activated medium on cells. Therefore, future in vitro studies should be done in media with similar pyruvate content.

中文翻译：

丙酮酸在低温冷血浆处理中作为细胞保护剂：对选择性杀死肿瘤细胞的基础研究的影响

在体外使用冷大气压血浆（CAP）报道了关于选择性杀死肿瘤细胞的有前途的研究。丙酮酸是细胞培养基中的一种补充剂，可以保护细胞免受活性氧的作用。在这里，我们提供了有关通过CAP选择性杀伤肿瘤细胞的体外研究的概述，特别强调了细胞培养基中丙酮酸的浓度。以前的一些研究是在丙酮酸含量不同的培养基中进行的。我们的细胞实验证实，丙酮酸减轻了血浆活化培养基对细胞的作用。因此，将来应在丙酮酸含量相似的培养基中进行体外研究。

更新日期：2019-09-18

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