The improvement of the stability of fucoxanthin in gastrointestinal tract is an important approach to enhance its edible efficacy. In this study, we designed complex carriers, which were composed by gum Arabic/gelatin microcapsules and alginate hydrogel beads (GA/GE/Alg-Beads), as gastric acid resistant vehicles for oral delivery of fucoxanthin. Various parameters of the obtained fucoxanthin loaded GA/GE/Alg-Beads (FX:GA/GE/Alg-Beads) were characterized. In vitro release rate assay showed that more than 90% of the encapsulated fucoxanthin was released in simulated intestine fluid (SIF), indicated the beads could protect fucoxanthin while incubated in simulated gastric fluid (SGF). In vivo oral efficacy assay exhibited that FX:GA/GE/Alg-Beads could more effectively lower the blood lipid and oxidative stress level of experimental mice than free fucoxanthin. These results demonstrated the beads are favorable oral delivery systems for fucoxanthin and other biologically active substances which are unstable in gastric acid.

岩藻黄质在胃肠道中的稳定性的提高是提高其食用功效的重要途径。在这项研究中，我们设计了由阿拉伯胶/明胶微胶囊和藻酸盐水凝胶珠（GA / GE / Alg-Beads）组成的复杂载体，作为口服递送岩藻黄质的耐胃酸载体。表征了所获得的黄藻黄质负载的GA / GE / Alg-Beads（FX：GA / GE / Alg-Beads）的各种参数。体外释放速率测定表明，在模拟肠液（SIF）中有超过90％的包裹的岩藻黄质被释放，这表明珠子在模拟胃液（SGF）中孵育时可以保护岩藻黄质。体内口服功效分析表明，FX：GA / GE / Alg-Beads可以比游离岩藻黄质更有效地降低实验小鼠的血脂和氧化应激水平。这些结果表明，该珠粒对于岩藻黄质和其他在胃酸中不稳定的生物活性物质是有利的口服递送系统。