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Advances in nanomedicine for cancer starvation therapy.
Theranostics ( IF 12.4 ) Pub Date : 2019-10-17 , DOI: 10.7150/thno.38261 Shuangjiang Yu 1, 2 , Zhaowei Chen 3 , Xuan Zeng 3 , Xuesi Chen 2 , Zhen Gu 3
Theranostics ( IF 12.4 ) Pub Date : 2019-10-17 , DOI: 10.7150/thno.38261 Shuangjiang Yu 1, 2 , Zhaowei Chen 3 , Xuan Zeng 3 , Xuesi Chen 2 , Zhen Gu 3
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Abnormal cell metabolism with vigorous nutrition consumption is one of the major physiological characteristics of cancers. As such, the strategy of cancer starvation therapy through blocking the blood supply, depleting glucose/oxygen and other critical nutrients of tumors has been widely studied to be an attractive way for cancer treatment. However, several undesirable properties of these agents, such as low targeting efficacy, undesired systemic side effects, elevated tumor hypoxia, induced drug resistance, and increased tumor metastasis risk, limit their future applications. The recent development of starving-nanotherapeutics combined with other therapeutic methods displayed the promising potential for overcoming the above drawbacks. This review highlights the recent advances of nanotherapeutic-based cancer starvation therapy and discusses the challenges and future prospects of these anticancer strategies.
中文翻译：
癌症饥饿疗法纳米医学的进展。
细胞代谢异常和营养消耗旺盛是癌症的主要生理特征之一。因此，通过阻断血液供应、消耗肿瘤的葡萄糖/氧气和其他关键营养物质来进行癌症饥饿治疗的策略已被广泛研究为一种有吸引力的癌症治疗方式。然而，这些药物的一些不良特性，例如靶向功效低、不良的全身副作用、肿瘤缺氧加剧、诱导耐药性和肿瘤转移风险增加等，限制了它们未来的应用。最近开发的饥饿纳米疗法与其他治疗方法相结合，显示出克服上述缺点的巨大潜力。这篇综述重点介绍了基于纳米疗法的癌症饥饿疗法的最新进展，并讨论了这些抗癌策略的挑战和未来前景。
更新日期：2019-10-17
中文翻译：
癌症饥饿疗法纳米医学的进展。
细胞代谢异常和营养消耗旺盛是癌症的主要生理特征之一。因此，通过阻断血液供应、消耗肿瘤的葡萄糖/氧气和其他关键营养物质来进行癌症饥饿治疗的策略已被广泛研究为一种有吸引力的癌症治疗方式。然而，这些药物的一些不良特性，例如靶向功效低、不良的全身副作用、肿瘤缺氧加剧、诱导耐药性和肿瘤转移风险增加等，限制了它们未来的应用。最近开发的饥饿纳米疗法与其他治疗方法相结合，显示出克服上述缺点的巨大潜力。这篇综述重点介绍了基于纳米疗法的癌症饥饿疗法的最新进展，并讨论了这些抗癌策略的挑战和未来前景。
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