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Stimuli‐Responsive Scaffold for Breast Cancer Treatment Combining Accurate Photothermal Therapy and Adipose Tissue Regeneration
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-07-17 , DOI: 10.1002/adfm.201904401 Guo Bai 1, 2 , Pingyun Yuan 2 , Bolei Cai 3 , Xinyu Qiu 4 , Ronghua Jin 2 , Shiyu Liu 4 , Yan Li 3 , Xin Chen 2
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-07-17 , DOI: 10.1002/adfm.201904401 Guo Bai 1, 2 , Pingyun Yuan 2 , Bolei Cai 3 , Xinyu Qiu 4 , Ronghua Jin 2 , Shiyu Liu 4 , Yan Li 3 , Xin Chen 2
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Development of new therapeutic scaffolds to selectively destruct tumors under gentle conditions meanwhile promoting adipose tissue formation would be a promising strategy for clinical treatment of breast cancer. Herein, a stimuli‐responsive scaffold composed of polyacrylic acid‐g‐polylactic acid (PAA‐g‐PLLA) modified graphene oxide (GO) with a cleavable bond in between (GO‐PAA‐g‐PLLA), gambogic acid (GA), and polycaprolactone (PCL) is fabricated and then preseeded on adipose‐derived stem cells (ADSCs) for breast cancer treatment. This GO–GA‐polymer scaffold is able to simultaneously perform pH‐triggered low temperature (45 °C) photothermal therapy to selectively induce the apoptosis of tumor cells and significantly improve ADSCs growth without any photothermal damage. The low‐temperature photothermal therapy of the scaffolds can induce more than 95% of cell death for human breast cancer (MCF‐7) in vitro, which further completely inhibits tumor growth and finally eliminates tumor tissue in mice. Meanwhile, the prepared GO–GA‐polymer scaffold possesses the improved capability to stimulate the differentiation of ADSCs into adipocytes by upregulating adipo‐related gene expression, and significantly promotes new adipose tissue formation whether with or without NIR irradiation. These results successfully demonstrate that the prepared GO–GA‐polymer scaffolds with bifunctional properties will be a promising candidate for clinical cases involving both tumor treatment and tissue engineering.
中文翻译：
刺激响应支架，结合精确的光热疗法和脂肪组织再生治疗乳腺癌。
开发新的治疗性支架以在温和的条件下选择性破坏肿瘤，同时促进脂肪组织的形成，将是乳腺癌临床治疗的一种有前途的策略。在这里，一个由聚丙烯酸-g-聚乳酸（PAA- g- PLLA）改性的氧化石墨烯（GO）组成的刺激响应支架，其间具有可裂解的键（GO-PAA- g‐PLLA），藤黄酸（GA）和聚己内酯（PCL）制成，然后预先接种在脂肪干细胞（ADSC）上进行乳腺癌治疗。这种GO–GA聚合物支架能够同时执行pH触发的低温（45°C）光热疗法，以选择性诱导肿瘤细胞的凋亡，并显着改善ADSC的生长而不会受到任何光热损伤。支架的低温光热疗法可在体外诱发人类乳腺癌（MCF-7）超过95％的细胞死亡，从而进一步完全抑制肿瘤生长并最终消除小鼠的肿瘤组织。同时，制备的GO–GA聚合物支架通过上调与脂肪相关的基因表达，具有刺激ADSCs分化为脂肪细胞的能力。无论有无NIR照射，均可显着促进新脂肪组织的形成。这些结果成功地表明，制备的具有双功能特性的GO-GA聚合物支架将成为涉及肿瘤治疗和组织工程的临床案例的有前途的候选者。
更新日期：2019-07-17
中文翻译：
刺激响应支架，结合精确的光热疗法和脂肪组织再生治疗乳腺癌。
开发新的治疗性支架以在温和的条件下选择性破坏肿瘤，同时促进脂肪组织的形成，将是乳腺癌临床治疗的一种有前途的策略。在这里，一个由聚丙烯酸-g-聚乳酸（PAA- g- PLLA）改性的氧化石墨烯（GO）组成的刺激响应支架，其间具有可裂解的键（GO-PAA- g‐PLLA），藤黄酸（GA）和聚己内酯（PCL）制成，然后预先接种在脂肪干细胞（ADSC）上进行乳腺癌治疗。这种GO–GA聚合物支架能够同时执行pH触发的低温（45°C）光热疗法，以选择性诱导肿瘤细胞的凋亡，并显着改善ADSC的生长而不会受到任何光热损伤。支架的低温光热疗法可在体外诱发人类乳腺癌（MCF-7）超过95％的细胞死亡，从而进一步完全抑制肿瘤生长并最终消除小鼠的肿瘤组织。同时，制备的GO–GA聚合物支架通过上调与脂肪相关的基因表达，具有刺激ADSCs分化为脂肪细胞的能力。无论有无NIR照射，均可显着促进新脂肪组织的形成。这些结果成功地表明，制备的具有双功能特性的GO-GA聚合物支架将成为涉及肿瘤治疗和组织工程的临床案例的有前途的候选者。
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