An investigation of the n-BuOH fraction of Schnabelia nepetifolia (Benth.) P.D.Cantino led to the isolation and identification of 12 undescribed phenylethanoid glycosides (nepetifosides A-L) and one undescribed phenylmethanoid glycoside (nepetifoside M), together with 23 known compounds. The structures of these compounds were determined by spectroscopic analyses including two-dimensional nuclear-magnetic-resonance (2D-NMR) spectroscopy and chemical-hydrolysis methods. Nepetifoside F exhibited strong activity that significantly increased osteoblast proliferation at three concentrations of 0.1, 1, and 10 μM. Moreover, nepetifoside C and nepetifoside D exhibited moderate activities in promoting the proliferation of osteoblasts at medium and high concentrations of 1 μM and 10 μM, respectively.

中文翻译：

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来自 Schnabelia nepetifolia (Benth.) PDCantino 的苯乙醇苷促进成骨细胞的增殖

对 Schnabelia nepetifolia (Benth.) PDCantino 的 n-BuOH 部分的研究导致分离和鉴定了 12 种未描述的苯乙醇苷（nepetifosides AL）和一种未描述的苯甲醇苷（nepetifoside M），以及 23 种已知化合物。这些化合物的结构是通过光谱分析确定的，包括二维核磁共振 (2D-NMR) 光谱和化学水解方法。Nepetifoside F 表现出很强的活性，在 0.1、1 和 10 μM 三个浓度下显着增加成骨细胞增殖。此外，nepetifoside C 和 nepetifoside D 分别在 1 μM 和 10 μM 的中浓度和高浓度下表现出中等浓度的促进成骨细胞增殖的活性。