2H-Azirines are versatile building blocks for the preparation of various nitrogen-containing heterocycles. Seven years ago the comprehensive review on azirine chemistry was published in Tetrahedron. Since then, there had been an explosion of research activities in the field of these strained molecules. This renaissance is primarily associated with the discovery of new reactivity of azirines and in particular new catalytic and light-induced reactions, which made possible unusual transformations of this three-membered N-heterocycle into azole and azine derivatives as well as polyheterocyclic systems. The second reason for the progress of azirine chemistry is the development of methods for the preparation of new azirine derivatives. The third reason is the discovery of new synthetic equivalents of azirines, which permitted avoiding the use of unstable azirines in some modern catalytic procedures. In the present comprehensive review, we have placed particular emphasis on discussing the new developments in the synthesis and reactivity of azirines for the period from 2012 until the end of 2018.

2 H-叠氮基是用于制备各种含氮杂环的通用构建基块。七年前，关于叠氮化物化学的综合评论发表在四面体上。从那时起，这些应变分子领域的研究活动激增。这种复兴主要与发现叠氮基的新反应性有关，尤其是新的催化和光诱导反应，这使得这种三元氮的异常转化成为可能。杂环形成吡咯和嗪衍生物以及多杂环体系。叠氮化学进展的第二个原因是制备新叠氮衍生物的方法的发展。第三个原因是发现了新的叠氮化物等效物，这可以避免在某些现代催化方法中使用不稳定的叠氮化物。在本次全面审查中，我们特别强调了讨论2012年至2018年底期间叠氮基化合物的合成和反应性的新发展。