An efficient synthesis of the p-toluenesulphonate salt of 3,6-dideoxy-3,6-imino 1,2-0-isopropylidene-α-D-glucofuranose (1) from glucose is reported; the potential of (1) in making hydroxylated pyrrolidines is illustrated by the preparation of 1,4-dideoxy-1,4-imino-L-gulitol, 1,4-dideoxy-1,4-imino-D-lyxitol (a powerful α galactosidase inhibitor), 2S,3S,4R-3,4-dihydroxyproline and (1S,2R,8S,8aR)-1,2,6 trihydroxyoctahydroindolizine [8-epi-Swainsonine]. An X-ray crystal structure of (1S,2R,83,8aR)-1,2,8-trihydroxy-5-oxo-octahydroindolizine is reported.

中文翻译：

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3，6-二脱氧-3，6-亚氨基-1，2-邻-异亚丙基-α-d-呋喃葡萄糖，作为发散中间体，用于合成羟基化的吡咯烷；1,4双脱氧-1,4-亚氨基-1-古洛糖醇，1,4-二脱氧-i，4-亚氨基-d-木糖醇，2S，3S，4R-3,4-二羟基脯氨酸和（1S，2R， 8S，8aR）-1，2，8-三羟基八氢吲哚嗪[8-表swainsonine]。（1S，2R，8S，8aR）-1,2,8-三羟基-5-氧代八氢吲哚嗪的X射线晶体结构

据报道由葡萄糖有效合成了3,6-二脱氧-3,6-亚氨基1,2-0-异亚丙基-α-D-葡萄糖呋喃糖（1）的对甲苯磺酸盐；（1）在制备羟基化吡咯烷中的潜力可通过制备1,4-二脱氧-1,4-亚氨基-L-古洛糖醇，1,4-二脱氧-1,4-亚氨基-D-木糖醇（ α半乳糖苷酶抑制剂），2S，3S，4R-3,4-二羟基脯氨酸和（1S，2R，8S，8aR）-1,2,6三羟基八氢吲哚嗪[8-表-Swainsonine]。报道了（1S，2R，83，8aR）-1，2，8-三羟基-5-氧代-八氢吲哚嗪的X射线晶体结构。