A Highly stereoselective Gabriel reaction via dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary was exploited. The reaction of tert-butyl (4S)-1-methyl-3-(2-bromopropionyl)-2-oxoimidazolidine-4-carboxylate (2a) with potassium phthalimide at room temperature predominantly afforded in a good yield which was derived to derivative (7) by removal of the chiral auxiliary.

中文翻译：

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利用2-氧代咪唑烷-4-羧酸酯作为手性助剂的动态动力学拆分：通过加百利反应立体选择性合成α-氨基酸

通过利用2-氧代咪唑烷-4-羧酸酯作为手性助剂的动态动力学拆分，进行了高度立体选择性的加百列反应。在室温下，叔丁基（4S）-1-甲基-3-（2-溴丙酰基）-2-氧代咪唑烷-4-羧酸酯（2a）与邻苯二甲酰亚胺钾的反应主要以良好的收率得到，其衍生为衍生物。 （7）通过除去手性助剂。