Single-Molecule Monitoring of the Structural Switching Dynamics of Nucleic Acids through Controlling Fluorescence Blinking,Angewandte Chemie International Edition

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Single-Molecule Monitoring of the Structural Switching Dynamics of Nucleic Acids through Controlling Fluorescence Blinking
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-10-24 06:13:03 , DOI: 10.1002/anie.201708705
Kiyohiko Kawai ₁ , Takafumi Miyata ₂ , Naohiko Shimada ₂ , Syoji Ito ₃ , Hiroshi Miyasaka ₃ , Atsushi Maruyama ₂

Affiliation

On the blink: The structural switching dynamics of nucleic acids between hairpin loop and stem structures were investigated at the single-molecule level by kinetic analysis based on the control of fluorescence blinking (KACB). Fast blinking is observed for a fluorophore at a hairpin loop, whereas blinking is slow when the fluorophore is buried in a stem.

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