当前位置: X-MOL 学术ACS Nano › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Physical Principles of Nanoparticle Cellular Endocytosis
ACS Nano ( IF 15.8 ) Pub Date : 2015-08-21 00:00:00 , DOI: 10.1021/acsnano.5b03184
Sulin Zhang 1, 2 , Huajian Gao 3 , Gang Bao 4
Affiliation  

This review article focuses on the physiochemical mechanisms underlying nanoparticle uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between the nanoparticles and the cell membrane generate forces from different origins. This leads to the membrane wrapping of the nanoparticles followed by cellular uptake. This article discusses how the kinetics, energetics, and forces are related to these interactions and dependent on the size, shape, and stiffness of nanoparticles, the biomechanical properties of the cell membrane, as well as the local environment of the cells. The discussed fundamental principles of the physiochemical causes for nanoparticle–cell interaction may guide new studies of nanoparticle endocytosis and lead to better strategies to design nanoparticle-based approaches for biomedical applications.

中文翻译:

纳米颗粒细胞内吞作用的物理原理

这篇综述文章重点介绍了纳米颗粒摄取进入细胞的理化机制。当纳米粒子紧邻细胞时,纳米粒子与细胞膜之间的相互作用会产生来自不同来源的力。这导致纳米颗粒的膜包裹,随后被细胞吸收。本文讨论了动力学,能量和力如何与这些相互作用相关联,并取决于纳米粒子的大小,形状和刚度,细胞膜的生物力学特性以及细胞的局部环境。讨论的引起纳米粒子与细胞相互作用的物理化学原因的基本原理可以指导纳米粒子内吞作用的新研究,并为设计基于纳米粒子的生物医学方法提供更好的策略。
更新日期:2015-08-21
down
wechat
bug