Synthesis of a unique fatty acyl unit to build the N-terminus of callipeltin A and homophymine B is described. Our approach to access (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid uses enzymatic hydrolysis for the desymmetrization of achiral acetate, followed by diastereoselective Roush crotylboration and Wittig olefination for the backbone construction.

中文翻译：

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酶法脱甲基制备（2R，3R，4R）-3-羟基-2,4,6-三甲基庚酸

描述了独特的脂肪酰基单元的合成以构建卡培尔汀A和高草甘膦B的N-末端。我们获得（2R，3R，4R）-3-羟基-2,4,6-三甲基庚酸的方法是使用酶促水解进行非手性乙酸酯的去对称化，然后进行非对映选择性的Roush烷基硼酸酯化和Wittig烯烃化来构建骨架。