C-reactive protein (CRP) has long been recognized as a marker of inflammation, but its evolving role in immunomodulation and cancer has increasingly been recognized. In recent years, multiple studies have explored CRP as a biomarker for prognosis and therapy response, particularly in the context of cancer immunotherapy. In this issue of Cancer Research, Feng and colleagues investigate the role of CRP in the development of lung metastasis. They provide evidence for a direct role of CRP acting together with commensal bacteria to instruct an immune-tolerant state of pulmonary macrophages through Fc gamma receptor IIb signaling. By suppressing immune surveillance in the lungs, CRP facilitates the formation of a premetastatic niche, allowing circulating tumor cells to establish metastases. See related article by Feng et al., p. 4184

中文翻译：

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C 反应蛋白促进肺部转移前生态位的形成


C 反应蛋白 （CRP） 长期以来一直被认为是炎症的标志物，但它在免疫调节和癌症中不断发展的作用已日益得到认可。近年来，多项研究探索了 CRP 作为预后和治疗反应的生物标志物，尤其是在癌症免疫治疗的背景下。在本期《癌症研究》中，Feng 及其同事研究了 CRP 在肺转移发展中的作用。它们提供了证据，证明 CRP 与共生菌一起作用，通过 Fc γ 受体 IIb 信号传导指示肺巨噬细胞的免疫耐受状态。通过抑制肺部的免疫监视，CRP 促进了转移前生态位的形成，使循环肿瘤细胞能够建立转移。参见 Feng 等人的相关文章，第 4184 页