Idiopathic inflammatory myopathies (myositis, IIMs) are rare, systemic autoimmune disorders that lead to muscle inflammation, weakness, and extra-muscular manifestations, with a strong genetic component influencing disease development and progression. Previous genome-wide association studies identified loci associated with IIMs. In this study, we imputed data from two prior genome-wide myositis studies and analyzed the largest myositis dataset to date to identify novel risk loci and susceptibility genes associated with IIMs and its clinical subtypes.

中文翻译：

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荟萃分析揭示了特发性炎性肌病的遗传结构


特发性炎症性肌病（肌炎，IIMs）是罕见的系统性自身免疫性疾病，可导致肌肉炎症、无力和肌外表现，具有很强的遗传成分影响疾病的发展和进展。以前的全基因组关联研究确定了与 IIMs 相关的基因座。在这项研究中，我们估算了来自先前两项全基因组肌炎研究的数据，并分析了迄今为止最大的肌炎数据集，以确定与 IIMs 及其临床亚型相关的新风险位点和易感基因。