The west Africa Ebola disease epidemic (2014–16) marked a historic change of course for patient care during emerging infectious disease outbreaks. The epidemic response was a failure in many ways—a slow, cumbersome, and disjointed effort by a global architecture that was not fit for purpose for a rapidly spreading outbreak. In the most affected countries, health-care workers and other responders felt helpless—dealing with an overwhelming number of patients but with few, if any, tools at their disposal to provide high-quality care. These inadequacies, however, led to attention and innovation. The decade since then has seen remarkable achievements in clinical care for Ebola disease, including the approval of the first vaccines and treatments. In this paper, the first in a two-part Series, we reflect on this progress and provide expert summary of the modern landscape of Ebola disease, highlighting the priorities and ongoing activities aimed at further improving patient survival and wellbeing in the years ahead.

中文翻译：

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埃博拉病：科学发现与临床应用的桥梁


西非埃博拉病流行（2014-16 年）标志着新发传染病爆发期间患者护理的进程发生了历史性变化。疫情应对在许多方面都是失败的 — 一个全球架构的缓慢、繁琐且脱节的努力，不适合快速蔓延的疫情。在受影响最严重的国家/地区，医护人员和其他响应者感到无助——他们要应对大量患者，但他们几乎没有（如果有的话）可用的工具来提供高质量的护理。然而，这些不足导致了关注和创新。从那时起的十年里，埃博拉病的临床护理取得了显著成就，包括第一批疫苗和治疗方法的批准。在本白皮书中，我们回顾了这一进展，并对埃博拉疾病的现代形势进行了专家总结，强调了旨在在未来几年进一步提高患者生存率和福祉的优先事项和正在进行的活动。