Correction: The following paragraph previously on page 11691 is now the footnote for Table 12 on page 11693. “Data are mean ± SEM measured as percent food intake relative to vehicle in rats after a single sc injection of 30 nmol/kg of the test substance. Data for cagrilintide have been published previously⁷ giving rise to 85% and 84% reduction of food intake in the periods from 0–24 h and 24–48 h, respectively. SEM is the standard error of the mean.” Correction: The following paragraph was previously included as the footnotes for Table 9 on page 11692 and has been moved to page 11691. “From the in vitro data (Tables 10 and 11), it was apparent that selectivity was achieved for several peptides (10, 14, 15, 16, 17, 18, 20, and 21). From the ThT assay (Table 9 and Supporting Information), only three of the AMYR selective peptides (14, 16, and 21) were able to resist physical stress for more than 40 h. Two peptides (15 and 21) had a selectivity ratio above 30. Peptide 6 and peptides 11–21 with neutral/high pI were chosen for further evaluation in vivo to evaluate their ability to reduce food intake in rats after a single administration and to have increased insights into the duration of effects from the peptides in vivo (Table 11).” This article has not yet been cited by other publications.

中文翻译：

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更正为“NN1213 – 人胰岛淀粉样肽的强效、长效和选择性类似物”


更正：之前在第 11691 页的以下段落现在是第 11693 页表 12 的脚注。“数据是 SEM 的平均±测量为大鼠在单次皮下注射 30 nmol/kg 测试物质后相对于载体的食物摄入量百分比。cagrilintide 的数据之前已发表⁷，导致 85-84 h 和 0-24 h 期间的食物摄入量分别减少了 24% 和 48%。SEM 是均值的标准误差。校正：以下段落以前作为第 11692 页表 9 的脚注包含在内，现已移至第 11691 页。“从体外数据（表 10 和 11）中可以明显看出，几种肽（10、14、15、16、17、18、20 和 21）都实现了选择性。从 ThT 测定（表 9 和支持信息）中，只有三种 AMYR 选择性肽 （14、16 和 21） 能够抵抗物理应激超过 40 小时。两种肽段（15 和 21）的选择性比高于 30。选择具有中性/高 pI 的肽 6 和肽 11-21 进行体内进一步评估，以评估它们在单次给药后减少大鼠食物摄入量的能力，并增加对体内肽作用持续时间的了解（表 11）。本文尚未被其他出版物引用。