Time-restricted eating (TRE) is a type of intermittent fasting (IF). Food can be consumed as desired during the eating period, but not during the remainder of the day. Studies suggest that many of the health benefits of fasting may not simply be the result of weight loss, but also due to the body’s responses to the fasting that lead to improved metabolic functioning. While animal studies are convincing regarding the benefits of time restricted feeding, human (TRE) studies are less consistent and generally short term (< 1 year). In 2020, the National Cancer Institute (NCI) funded five IF studies, four of which focused on TRE, which addressed the question “How does intermittent fasting affect cancer incidence, treatment response, or outcome?” NCI sponsored a webinar in 2023 featuring investigators of the funded studies in which they discussed challenges as well as their thoughts regarding the most important TRE topics that should be addressed going forward. Six areas were identified, which are discussed below as well as in a recently published NOT-CA-24-073: Factors impacting how Time-Restricted Eating (TRE) influences cancer-related outcomes. Moving the science forward will allow the scientific community to better understand TRE’s potential. This potential includes the development of targeted TRE interventions to optimize long-term adherence to the intervention, which is required to better understand fully explore its potential benefits in cancer risk, increased response to cancer treatment, as well as improved quality and quantity of life among cancer survivors.

中文翻译：

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限时饮食与癌症：经验教训和前进道路的考虑


限时进食 （TRE） 是一种间歇性禁食 （IF）。食物可以在进食期间随心所欲地食用，但不能在一天的其余时间内食用。研究表明，禁食的许多健康益处可能不仅仅是减肥的结果，还由于身体对禁食的反应导致新陈代谢功能得到改善。虽然动物研究关于限时喂养的好处令人信服，但人类 （TRE） 研究不太一致，而且通常是短期的（1 年 <）。2020 年，美国国家癌症研究所 （NCI） 资助了 5 项 IF 研究，其中 4 项侧重于 TRE，该研究解决了“间歇性禁食如何影响癌症发病率、治疗反应或结果”的问题。NCI 在 2023 年赞助了一次网络研讨会，由受资助研究的研究人员参加，他们在其中讨论了挑战以及他们对未来应该解决的最重要的 TRE 主题的想法。确定了六个领域，下面以及最近发布的 NOT-CA-24-073：影响限时饮食 （TRE） 如何影响癌症相关结果的因素进行了讨论。推动科学向前发展将使科学界更好地了解 TRE 的潜力。这种潜力包括开发有针对性的 TRE 干预措施以优化对干预的长期依从性，这是更好地了解充分探索其在癌症风险、增加对癌症治疗的反应以及提高癌症幸存者生活质量和数量方面的潜在益处所必需的。