Adult stem cells maintain homeostasis and enable regeneration of most tissues. Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly regulated processes governed by dynamic transcriptional, epigenetic, and metabolic programs. Previously thought to merely reflect a cell's energy state, metabolism is now recognized for its critical regulatory functions, controlling not only energy and biomass production but also the cell's transcriptome and epigenome. In this review, we explore how metabolic pathways, metabolites, and transcriptional and epigenetic regulators are functionally interlinked in adult and aging skeletal muscle stem cells.

中文翻译：

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成人和衰老骨骼肌干细胞的代谢调节


成体干细胞维持体内平衡并实现大多数组织的再生。干细胞及其祖细胞的静止、增殖和分化是受动态转录、表观遗传和代谢程序控制的严格调控过程。以前认为新陈代谢仅反映细胞的能量状态，现在人们认识到其关键的调节功能，不仅控制能量和生物量的产生，还控制细胞的转录组和表观基因组。在这篇综述中，我们探讨了成人和衰老骨骼肌干细胞中的代谢途径、代谢物以及转录和表观遗传调节因子如何在功能上相互关联。