Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disease that leads to severe joint damage and disability. Conventional treatment options are limited by their efficacy and side effect profiles. Nanozymes, nanomaterials with enzyme-like activities, offer a novel therapeutic approach for RA. This review summarizes recent advances in nanozyme-based treatments, focusing on their antioxidant and immunomodulatory roles in mitigating RA. We discuss various nanozymes, including those based on cerium, iron, manganese, silver, copper, platinum, rhodium, and multi-metallic nanozymes, which mimic natural enzymes such as superoxide dismutase, catalase, and peroxidase to reduce oxidative stress. Additionally, we explore nanozyme-based combination therapies that integrate with other strategies, such as vesicles and phototherapy, to achieve synergistic effects and enhance efficacy. This review highlights the significant potential of nanozymes in improving RA treatment, offering a new perspective for future research and clinical applications.

中文翻译：

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基于纳米酶的类风湿性关节炎治疗策略


类风湿性关节炎 （RA） 是一种普遍的慢性自身免疫性疾病，可导致严重的关节损伤和残疾。常规治疗方案受其疗效和副作用的限制。纳米酶是具有酶样活性的纳米材料，为 RA 提供了一种新的治疗方法。本文总结了基于纳米酶的治疗的最新进展，重点介绍了它们在缓解 RA 中的抗氧化和免疫调节作用。我们讨论了各种纳米酶，包括基于铈、铁、锰、银、铜、铂、铑和多金属纳米酶的纳米酶，它们模拟超氧化物歧化酶、过氧化氢酶和过氧化物酶等天然酶来减少氧化应激。此外，我们探索了基于纳米酶的联合疗法，这些疗法与其他策略（如囊泡和光疗）相结合，以实现协同效应并提高疗效。本文重点介绍了纳米酶在改善 RA 治疗方面的巨大潜力，为未来的研究和临床应用提供了新的视角。